Interaction of histamine H2-receptor blocking drugs with the noradrenergic system in rat brain and heart

European Journal of Pharmacology
J Z Nowak

Abstract

The i.v.t. injection of burimamide (BUR), 50 micrograms, or cimetidine (CIM), 250 micrograms, decreased significantly the hypothalamic noradrenaline (NA) content by 32 and 21%, and significantly increased the whole brain 3-methoxy-4-hydroxyphenylglycol level by 46 and 28%, respectively. The i.p. administration of BUR or metiamide (MET), at a dose of 50 mg/kg, caused a decrease in the rat heart NA content by 34 and 21%, respectively; CIM had no effect at doses up to 100 mg/kg i.p., whether given acutely or chronically.

Citations

Jul 1, 1984·The Journal of Pharmacy and Pharmacology·N K DadkarA N Dohadwalla

Related Concepts

Metazoa
Brain
Burimamide
Tagamet
Histamine H2 Antagonists
Metiamide Monohydrochloride
Myocardium
Norepinephrine, (+, -)-Isomer
Rats, Laboratory

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.