Abstract
Histologic grade is considered the paramount prognostic factor in predicting survival for soft-tissue sarcomas (STS). Increasing data suggest that histologic type substantially impacts STS behavior. The Surveillance, Epidemiology, and End Results program was used to identify 17,364 cases of STS diagnosed between 1988 and 2004. Using death from STS as 1 of the outcomes variables, histologic types were grouped into 3 categories: favorable (survival >or= 20% above the mean), neutral (survival within 20% of the mean), and unfavorable (survival >or= 20% below the mean). The effect of histology on survival was analyzed stratified by tumor grade. Five-year survival was calculated using Kaplan-Meier analysis. Among 73 histologic types, malignant fibrous histiocytoma (24.1%); leiomyosarcoma, not otherwise specified (14.8%); sarcoma, not otherwise specified (12.8%); and myxoid liposarcoma (5.9%) were the most prevalent. Grade distribution was as follows: low, 12.6%; intermediate, 14.9%; high, 37.1%; and unknown, 35.4%. Risk of death from STS increased with increasing grade: 8.0% for low, 25.9% for intermediate, and 38.3% for high. Among low-grade tumors, risk of death from STS ranged from 4.3% for favorable types to 15.3% for unfavorable...Continue Reading
References
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J GaynorM F Brennan
Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A Alvegård, N O Berg
Oct 1, 1989·Acta Orthopaedica Scandinavica·T A AlvegårdB Rööser
Jul 15, 1989·Cancer·M ShirakiE C Borden
Aug 1, 1989·Journal of Surgical Oncology·E E LackS A Rosenberg
Oct 1, 1989·Cancer·H R ChangM F Brennan
Jun 1, 1988·World Journal of Surgery·S I HajduM F Brennan
Jul 15, 1986·Cancer·J M CoindreJ F Goussot
Oct 1, 1984·American Journal of Clinical Oncology·M LopezC F Perno
Feb 1, 1984·Cancer·J CostaS A Rosenberg
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·M TrojaniC Lagarde
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M CoindreG Contesso
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S DaugaardM Harris
Jul 14, 1999·Seminars in Surgical Oncology·E A Levine
May 11, 2001·Cancer·J M CoindreB N'Guyen Bui
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanMurray F Brennan
Feb 2, 2002·Human Pathology·Tadashi HasegawaYoshihiro Matsuno
May 8, 2003·Annals of Surgical Oncology·Jonathan B KoeaMurray F Brennan
Oct 16, 2004·Cancer·Fritz C EilberMichael W Kattan
Dec 4, 2004·Cancer·Luigi MarianiAlessandro Gronchi
Dec 20, 2005·Histopathology·C D M Fletcher
Aug 24, 2006·Annals of Surgery·Kimberly Moore DalalSamuel Singer
May 22, 2007·The Journal of Surgical Research·Juan C GutierrezLeonidas G Koniaris
May 25, 2007·Annals of Surgery·Juan C GutierrezLeonidas G Koniaris
Jun 2, 2007·The Lancet Oncology·Jay S WunderBenjamin A Alman
Sep 28, 2007·Annals of Surgical Oncology·Karl Y BilimoriaDavid J Bentrem
Jul 12, 2008·Cancer·Panta RouhaniJorge R Toro
Oct 3, 2008·Annals of Surgical Oncology·Robert J CanterMurray F Brennan
Citations
Dec 3, 2010·Plastic and Reconstructive Surgery·Warren H TsengSteve R Martinez
Apr 25, 2012·Annals of Surgical Oncology·Jonathan Agner ForsbergMurray F Brennan
Mar 5, 2016·Frontiers in Surgery·Georgios KoulaxouzidisHolger Bannasch
Sep 17, 2011·The Journal of Surgical Research·Caitlin A SmithRobert J Canter
Jun 15, 2011·The Journal of Hand Surgery·Kai Megerle, Michael Sauerbier
Dec 24, 2010·The Journal of Surgical Research·Warren H Tseng, Steve R Martinez
Sep 2, 2014·Journal of Surgical Oncology·Khatija W NaingRobert J Canter
Jan 24, 2014·Sarcoma·Mei Sheng DuhBruce Wong
Jul 15, 2015·The Journal of Surgical Research·Noah K YuenRobert J Canter
Jun 13, 2015·Sarcoma·Alexander L LazaridesBrian E Brigman
Sep 4, 2016·Surgical Oncology Clinics of North America·Robert J Canter
Sep 15, 2016·The Journal of Small Animal Practice·J P Bray
Dec 9, 2010·Veterinary Pathology·M M DennisB E Powers
Feb 18, 2016·American Journal of Clinical Oncology·Xuanlu QuNabil Wasif
Sep 12, 2017·International Journal of Cancer. Journal International Du Cancer·Jeremy LewinAlbiruni R A Razak
Dec 9, 2017·Frontiers in Oncology·Bernard Séguin
Oct 5, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kim M BoerkampGerard R Rutteman
Oct 18, 2013·The Journal of Bone and Joint Surgery. American Volume·Benjamin K PotterAlexander Stojadinovic
Jan 17, 2012·Cancer·Andrea M AbbottWaddah Al-Refaie
Dec 18, 2015·Oncotarget·Parag P PatwardhanGary K Schwartz
Oct 27, 2015·Oncotarget·Alimujiang WushouZhi-Ming Shao
Jul 4, 2020·Journal of Orthopaedic Surgery·Mahmut Nedim AytekinAliekber Yapar
Jul 6, 2020·Cancer Biomarkers : Section a of Disease Markers·Linyan ChenXuelei Ma
Jul 31, 2018·Japanese Journal of Clinical Oncology·Ruping ZhaoShenglin Ma
Dec 19, 2019·Frontiers in Oncology·Johannes ZellerSteffen U Eisenhardt
Oct 31, 2020·Curēus·Ali Jawad Jang Khan, Noman Ahmed Jang Khan
Aug 3, 2021·International Journal of General Medicine·Sunny J PatelAchuta K Guddati
Aug 28, 2021·Frontiers in Surgery·Zaixing WangQiuhang Zhang
Sep 2, 2021·Cancer Management and Research·Aobo ZhuangWeiqi Lu