Interaction of histologic subtype and histologic grade in predicting survival for soft-tissue sarcomas

Journal of the American College of Surgeons
Robert J CanterAnthony S Robbins

Abstract

Histologic grade is considered the paramount prognostic factor in predicting survival for soft-tissue sarcomas (STS). Increasing data suggest that histologic type substantially impacts STS behavior. The Surveillance, Epidemiology, and End Results program was used to identify 17,364 cases of STS diagnosed between 1988 and 2004. Using death from STS as 1 of the outcomes variables, histologic types were grouped into 3 categories: favorable (survival >or= 20% above the mean), neutral (survival within 20% of the mean), and unfavorable (survival >or= 20% below the mean). The effect of histology on survival was analyzed stratified by tumor grade. Five-year survival was calculated using Kaplan-Meier analysis. Among 73 histologic types, malignant fibrous histiocytoma (24.1%); leiomyosarcoma, not otherwise specified (14.8%); sarcoma, not otherwise specified (12.8%); and myxoid liposarcoma (5.9%) were the most prevalent. Grade distribution was as follows: low, 12.6%; intermediate, 14.9%; high, 37.1%; and unknown, 35.4%. Risk of death from STS increased with increasing grade: 8.0% for low, 25.9% for intermediate, and 38.3% for high. Among low-grade tumors, risk of death from STS ranged from 4.3% for favorable types to 15.3% for unfavorable...Continue Reading

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Citations

Sep 17, 2011·The Journal of Surgical Research·Caitlin A SmithRobert J Canter
Jun 15, 2011·The Journal of Hand Surgery·Kai Megerle, Michael Sauerbier
Dec 24, 2010·The Journal of Surgical Research·Warren H Tseng, Steve R Martinez
Jul 15, 2015·The Journal of Surgical Research·Noah K YuenRobert J Canter
Sep 4, 2016·Surgical Oncology Clinics of North America·Robert J Canter
Sep 15, 2016·The Journal of Small Animal Practice·J P Bray
Dec 9, 2010·Veterinary Pathology·M M DennisB E Powers
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Dec 9, 2017·Frontiers in Oncology·Bernard Séguin
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Oct 18, 2013·The Journal of Bone and Joint Surgery. American Volume·Benjamin K PotterAlexander Stojadinovic
Jul 4, 2020·Journal of Orthopaedic Surgery·Mahmut Nedim AytekinAliekber Yapar
Jul 31, 2018·Japanese Journal of Clinical Oncology·Ruping ZhaoShenglin Ma
Dec 19, 2019·Frontiers in Oncology·Johannes ZellerSteffen U Eisenhardt

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