Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis.

Journal of Neurology, Neurosurgery, and Psychiatry
A PezziniA Padovani

Abstract

Whether the association between mild hyperhomocysteinaemia and ischaemic stroke is the consequence of a predisposing genetic background or is due to the confounding influence of established predisposing factors remains to be determined. Plasma total homocysteine (tHcy) concentration and the distribution of the C677T genotypes of the methylenetetrahydrofolate reductase gene (MTHFR) were compared in 174 consecutive patients with stroke aged <45 years and 155 age and sex-matched controls. The effect of conventional risk factors on the relationship between phenotype-disease and genotype-disease was analysed by two-way and three-way interaction analysis and by the classification and regression trees (CART) model. tHcy concentrations were markedly higher in patients with ischaemic stroke (median 11.9 micromol/l, range 2.0-94.0) than in controls (median 9.8 micromol/l, range 4.7-49.6). An increased risk was also associated with the TT677 genotype (odds ratio (OR) 1.98; 95% confidence interval (CI) 1.04 to 3.78) and with the T allele (1.40; 95% 1.03 to 1.92) of the MTHFR gene. A differential effect of Hcy levels on risk of stroke was observed according to the distribution of environmental-behavioural risk factors, with a stronger influ...Continue Reading

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Citations

Jun 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·V Caso, M Paciaroni
Jul 30, 2009·The Tohoku Journal of Experimental Medicine·Nida TascilarAysun Unal
May 21, 2010·Neurological Research·Qi BiZhe Song
Jul 2, 2010·Critical Reviews in Clinical Laboratory Sciences·Sanja Stankovic, Nada Majkic-Singh
Jan 7, 2014·Journal of Manipulative and Physiological Therapeutics·Chadwick L R ChungGeorges L'Espérance
Feb 27, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D LuD Sun
Aug 12, 2014·Cell Biochemistry and Biophysics·Wei ZhangGuorong Bi
Mar 19, 2016·International Journal of Cancer. Journal International Du Cancer·Xianhui QinYong Huo
Oct 26, 2016·Stroke; a Journal of Cerebral Circulation·Xianhui QinYong Huo

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