Interaction of human arylamine N-acetyltransferase 1 with different nanomaterials

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Zhou J DengR F Minchin

Abstract

Humans are exposed to nanoparticles in the environment as well as those in nanomaterials developed for biomedical applications. However, the safety and biologic effects of many nanoparticles remain to be elucidated. Over the past decade, our understanding of the interaction of proteins with various nanomaterials has grown. The protein corona can determine not only how nanoparticles interact with cells but also their biologic effects and toxicity. In this study, we describe the effects that several different classes of nanoparticles exert on the enzymatic activity of the cytosolic protein human arylamine N-acetyltransferase 1 (NAT1), a drug-metabolizing enzyme widely distributed in the body that is also responsible for the activation and detoxification of known carcinogens. We investigated three metal oxides (zinc oxide, titanium dioxide, and silicon dioxide), two synthetic clay nanoparticles (layered double hydroxide and layered silicate nanoparticles), and a self-assembling thermo-responsive polymeric nanoparticle that differ in size and surface characteristics. We found that the different nanoparticles induced very different responses, ranging from inhibition to marked enhancement of enzyme activity. The layered silicates did...Continue Reading

References

Feb 29, 2000·Molecular Pharmacology·N J ButcherR F Minchin
May 17, 2006·Acta Biomaterialia·Morton Ehrenberg, James L McGrath
Nov 2, 2007·Analytical Chemistry·Joseph A RyanDaniel L Feldheim
Jul 22, 2008·Drug Metabolism Reviews·Edith SimSotiria Boukouvala
Aug 6, 2008·Current Drug Metabolism·D M Grant
Oct 14, 2009·Nanotechnology·Zhou J DengRodney F Minchin
Jan 9, 2010·International Journal of Molecular Sciences·Zhaochun WuBing Yan
Nov 18, 2011·Pharmacological Reviews·Neville J Butcher, Rodney F Minchin
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Jan 10, 2013·Biomacromolecules·Nguyen T D TranMichael J Monteiro

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Citations

Sep 6, 2014·Biologie aujourd'hui·Armelle Baeza-Squiban
Oct 1, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sonja BolandArmelle Baeza-Squiban
Aug 31, 2018·Biomacromolecules·Wenyi GuMichael J Monteiro
Nov 16, 2018·Biomacromolecules·Valentin A BobrinMichael J Monteiro

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