Interaction of human plasma fibrinogen with commercially pure titanium as studied with atomic force microscopy and X-ray photoelectron spectroscopy

Langmuir : the ACS Journal of Surfaces and Colloids
Isabel Van De KeereJean Vereecken

Abstract

The surface of a biomaterial interacts with the body fluid upon implantation in the human body. The biocompatibility of a material is strongly influenced by the adsorption of proteins onto the surface. Titanium is frequently used as a biomaterial for implants in orthopedics and cardiovascular devices. Understanding the biocompatibility is very important to improve implants. The surface chemistry of an implant material and its influence on the interaction with body fluid is crucial in that perspective. The main goal of this study was to investigate the conformation of human plasma fibrinogen (HPF) adsorbed on commercially pure titanium (CP Ti) on a molecular level by means of ex situ atomic force microscopy (AFM). With X-ray photoelectron spectroscopy combined with argon ion beam depth profiling, it was shown that the oxide layer present at the surface was mainly composed of TiO2, with a small percentage of Ti2O3. Ex situ AFM imaging showed the conformation of HPF on CP Ti. Single molecules and aggregates of fibrinogen were observed. The trinodular structure of single HPF molecules (two spherical D domains at the distal ends of the extended molecule and the central spherical E domain) adsorbed onto CP Ti was visualized. Aggregat...Continue Reading

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Citations

Apr 16, 2011·The Journal of Physical Chemistry. B·Natalia HassanJuan M Ruso
Oct 5, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ivan S YermolenkoTatiana P Ugarova
May 26, 2010·The Analyst·Laurel E Averett, Mark H Schoenfisch
May 21, 2010·Physical Chemistry Chemical Physics : PCCP·Marta CornoPiero Ugliengo
Sep 8, 2012·Biointerphases·Jana SommerfeldCarsten Ronning
Jul 6, 2011·Colloids and Surfaces. B, Biointerfaces·Natalia HassanJuan M Ruso
Nov 13, 2010·Colloids and Surfaces. B, Biointerfaces·Natalia HassanP Somasundaran
Nov 17, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Stephan KöhlerGiovanni Settanni
May 8, 2009·Macromolecular Bioscience·José Carlos Rodríguez HernándezManuel Salmerón-Sánchez
Jul 13, 2011·Clinical Implant Dentistry and Related Research·Jaan HongAndreas Thor
Dec 3, 2014·Journal of Colloid and Interface Science·Rong WangEn-Tang Kang
Jul 5, 2011·Journal of Colloid and Interface Science·Natalia HassanJuan M Ruso
Mar 10, 2021·Macromolecular Bioscience·Stephani StamboroskiDorothea Brüggemann

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