PMID: 9159222Aug 1, 1996Paper

Interaction of human spermatozoa with the zona pellucida of oocyte: development of the acrosome reaction

Frontiers in Bioscience : a Journal and Virtual Library
Patricio Morales, M Llanos

Abstract

Mammalian spermatozoa are not able to fertilize an oocyte upon ejaculation. To gain fertilizing ability, spermatozoa must, either in vivo or in vitro, undergo a process termed capacitation. Since a reliable marker for capacitation does not exist, it is considered that this process is completed when the spermatozoa are able to undergo acrosomal x intestinal mucosa which might require tandem signaling events for this process is the presence of a vascular countercurrent arrangement in the subepithelial compartment. As happens for absorbed solutes, this countercurrent phenomenon may distort transepithelial solute gradient. For example, perfusion of mammalian intestinal loops in vivo with solutions containing fMLP was previously found to induce neutrophil attachment to endothelial cells and structurally defined endothelial activation, but failed to elicit directed migration across the lamina propria (Madara, unpublished observations), suggesting that directed migration may require a more stable gradient than that afforded by the usual soluble signals. For example, once present in inflamed tissue, IL-8 is likely to retain its biological activity for several hours, as shown by local intradermal administration in animals and humans. In...Continue Reading

Citations

Aug 26, 1998·Molecular Reproduction and Development·M N Llanos
Sep 26, 2002·Biology of Reproduction·Patricio MoralesEduardo Pizarro
Jan 4, 2001·Molecular Reproduction and Development·M N LlanosS Meizel
Feb 28, 2009·Biology of Reproduction·Pankaj BansalSatish K Gupta
Nov 22, 2002·Biology of Reproduction·W van BiljonJ Hapgood
Sep 15, 2005·Journal of Neuroendocrinology·J P HapgoodK Ronacher
Jun 29, 2005·Animal Reproduction Science·N RamakrishnappaP C K Leung

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