Interaction of Interceed oxidized regenerated cellulose with macrophages: a potential mechanism by which Interceed may prevent adhesions

American Journal of Obstetrics and Gynecology
S ReddyS Parthasarathy

Abstract

The objective of the study was to determine whether Interceed oxidized regenerated cellulose (Johnson & Johnson Medical, Arlington, Tex.), because of its polyanionic nature, may compete for the macrophage scavenger receptor. RAW macrophages were incubated with Interceed oxidized regenerated cellulose and known scavenger receptor ligands. The production of interleukin-1beta by mouse peritoneal macrophages was measured in the presence of Interceed cellulose. When macrophages were incubated with Interceed cellulose, increasing concentrations inhibited the uptake of fluorescent acetyl low-density lipoprotein. In the presence of Interceed cellulose there was a decrease in the production of interleukin-1beta by mouse macrophages. These results suggest that the interaction of Interceed oxidized regenerated cellulose with macrophages with scavenger receptors may result in a decreased secretion of matrix components, inflammatory mediators, and cellular growth factors. Thus Interceed cellulose may function as a biologic barrier in preventing adhesions.

References

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Citations

Oct 29, 2002·International Immunopharmacology·Markéta JelinkováBlanka Ríhová
Jan 25, 2011·Fertility and Sterility·Andrea TinelliLiselotte Mettler
May 12, 2009·Journal of Cellular and Molecular Medicine·Paul GutweinJosef Pfeilschifter
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Jul 12, 2020·Materials·Heekyung ParkDonghyun Lee
Jan 20, 2021·Macromolecular Bioscience·Arvind K Singh ChandelTaichi Ito
Jan 28, 2021·Surgical Technology International·Bernhard KrämerSascha Hoffmann

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