PMID: 2509817Nov 1, 1989Paper

Interaction of ketosis and liver regeneration in the rat

The Journal of Surgical Research
R H BirkhahnN R Thomford

Abstract

Monoacetoacetin, the monoglyceride of acetoacetate, was investigated as a nutritional support for the regenerating liver. Following partial hepatectomy, rats were either fed an oral diet ad libitum or administered by total parenteral feeding glucose alone, monoacetoacetin-glucose mixture, or lipid emulsion-glucose for the nonprotein calories. Five rats from each treatment were killed at 6-hr intervals beginning 12 hr after partial hepatectomy and ending at 72 hr. The number of cells synthesizing DNA and the number of cells in mitosis were compared. Rats fed orally or infused with glucose alone or with lipid emulsion had similar parameters throughout. Rats infused with monoacetoacetin had approximately double the number of cells in mitosis and DNA synthesis compared to the other treatments. This stimulation by monoacetoacetin persisted 72 hr. It was concluded from the data that acetoacetate was the agent responsible for increased DNA synthesis and mitosis, but the mechanism for the stimulation was not identified.

References

Mar 1, 1978·The American Journal of Clinical Nutrition·R H Birkhahn, J R Border
Jul 21, 1976·Biochimica Et Biophysica Acta·F L Shinnick, A E Harper
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·P RigottiJ E Fischer
May 1, 1986·The Journal of Nutrition·R H BirkhahnN R Thomford
Feb 1, 1988·The Journal of Surgical Research·D J BlockR H Birkhahn
Feb 1, 1988·The Journal of Surgical Research·R H BirkhahnN R Thomford
Oct 1, 1985·The Biochemical Journal·P S SchofieldM C Sugden
Jan 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·R H Birkhahn, J R Border
Jan 1, 1980·Physiological Reviews·A M Robinson, D H Williamson
Jan 19, 1981·Life Sciences·T NakataniT Tobe
Jan 1, 1963·International Review of Cytology·N L BUCHER

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Citations

Dec 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·V BláhaZ Zadák
Oct 6, 1998·The Journal of Surgical Research·Y PanisJ C Emond
May 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·R H BirkhahnN R Thomford
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M NagayamaR H Birkhahn
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·M H Chiu, R H Birkhahn

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