PMID: 2093835Jan 1, 1990Paper

Interaction of lactoferrin with Escherichia coli cells and correlation with antibacterial activity

Medical Microbiology and Immunology
P ViscaP Valenti

Abstract

It has been established that the antimicrobial activity of lactoferrin towards Escherichia coli is enhanced by a direct contact between the protein and the microbial cell and that, in the case of E. coli K-12 strains, an antibacterial activity of lactoferrin unrelated to iron withdrawal is present. Evidence is now reported that lactoferrin binds to surface structures expressed in E. coli K-12 strains grown in either an "excess" or "stress" of iron. Under the experimental conditions used, lactoferrin binding both in the apo and in the iron-saturated form yields a maximum of 1.6 X 10(5) bound molecules/E. coli K-12 cell; the amount of lactoferrin bound does not depend on the expression of the iron-regulated outer membrane proteins. In contrast, lactoferrin does not bind to E. coli clinical isolates. Apo-lactoferrin (at 500 micrograms/ml in a chemically defined medium) inhibits the growth of E. coli K-12 strains but not of clinical isolates. These findings suggest that the antibacterial activity of the protein could be associated to its binding to the cell surface.

Citations

Mar 1, 1996·Antiviral Research·M MarchettiL Seganti
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·P PudduL Seganti
Feb 1, 1995·Oral Microbiology and Immunology·K R AlugupalliA S Naidu
Aug 23, 2003·Infection and Immunity·Theresa J OchoaThomas G Cleary
May 5, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·David B AlexanderHiroyuki Tsuda
Jun 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mauricio AriasHans J Vogel
Oct 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Yasushi SasakiTakashi Okai
May 1, 1997·FEMS Microbiology Letters·A de Lillo, J F Fierro
Jun 29, 2004·Journal of Clinical Gastroenterology·Piera ValentiLucilla Seganti

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