Interaction of laxatives with enzymes of cyclic AMP metabolism from human colonic mucosa

European Journal of Clinical Investigation
B Simon, H Kather

Abstract

The mechanism by which laxatives such as dioctyl sodium sulfosuccinate and ricinoleic acid evoke colonic fluid secretion has been suggested to involve mucosal cyclic AMP. Ricinoleic acid and dioctyl sodium sulfosuccinate were tested for their capacity to modulate the key enzymes of cAMP-metabolism--adenylate cyclase and cAMP-phosphodiesterase--in human colonic mucosa. Both laxatives were ineffective stimuli of human colonic adenylate cyclase. In contrast to ricinoleic acid, dioctyl sodium sulfosuccinate was a competitive inhibitor of soluble cAMP-phosphodiesterase activity. These experiments suggest that the cathartic properties of dioctyl sodium sulfosuccinate in human colonic mucosa might be mediated by cyclic AMP via inhibition of soluble phosphodiesterase activity.

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Citations

Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H K SeitzS Veith
May 31, 2001·Alimentary Pharmacology & Therapeutics·L R Schiller
Nov 16, 2011·Journal of Medicinal Food·Esam Y QnaisShtaywy S Abdalla
Jul 8, 2000·Pediatric Annals·R Rockney
Nov 22, 2005·Journal of Ethnopharmacology·S AfrozM S K Choudhuri
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·H K SeitzB Kommerell
Dec 1, 1980·European Journal of Clinical Investigation·B Simon, H Kather
Jan 23, 1999·Journal of Clinical Gastroenterology·L R Schiller
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·H K SeitzB Kommerell

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