Interaction of leptin and nitric oxide pathway on penicillin-induced epileptiform activity in rats

Brain Research
Ali AslanErdal Agar

Abstract

The aim of the present study was to investigate the role of NO as a mediator of leptin action at the penicillin-induced epileptiform activity in rat. Thirty minutes after penicillin injection, leptin, at a dose of 1 microg, significantly increased the mean frequency of epileptiform activity without changing the amplitude. The effects of systemic administration of nitric oxide synthase (NOS) inhibitors, non-selective NG-nitro-L-arginine methyl ester (L-NAME), selective neuronal NOS inhibitor, 7-nitroindazole (7-NI) and NO precursor, L-arginine on the effects of leptin were investigated. The occurrence of anticonvulsant activity of 7-NI (40 mg/kg, i.p.) was significantly delayed in the presence of leptin (1 microg). The administration of L-NAME (60 mg/kg, i.p.), 30 min before leptin (1 microg) application, did not influence proconvulsant activity of leptin. The administration of L-arginine (1000 mg/kg, i.p.) 30 min before the effective dose of leptin (1 microg, i.c.v.) reversed the proconvulsant effects of leptin whereas the same dose of its inactive enantiomer, D-arginine (1000 mg/kg, i.p.) failed to influence the proconvulsant effect of leptin. The electrophysiological evidence of the present study suggests that neuronal NOS/NO...Continue Reading

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Citations

Oct 8, 2013·Acta Neuropathologica·Edward B Lee, Mark P Mattson
Aug 23, 2011·Epilepsy Research·Liu Lin Thio
Apr 17, 2015·Acta Neurologica Scandinavica·E Agar
May 9, 2014·Frontiers in Neurology·Carmela GiordanoGiuseppe Biagini
Sep 7, 2018·BMC Neuroscience·Laura Mora-MuñozAlberto Velez-van-Meerbeke

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