PMID: 11604264Oct 18, 2001Paper

Interaction of liposome formulations with human skin in vitro

International Journal of Pharmaceutics
G BetzG Imanidis

Abstract

The interaction of liposome formulations consisting of Phospholipon 80 and sphingomyelin with human skin was investigated. These formulations were shown previously to have a composition-dependent effect on the penetration of Heparin into the skin. Fluorescence labelled phosphatidylethanolamine (PE-NBD) was incorporated in the liposomes and the depth in which the fluorescent phospholipid label enters into epidermal membrane and full thickness skin was studied by confocal laser scanning microscopy (CLSM). Confocal sections parallel to the surface of the skin were recorded in heat separated epidermis. An even distribution of phospholipid in the lipid matrix of the stratum corneum surrounding the corneocytes was observed with Phospholipon 80 but not when sphingomyelin was included in the formulation. The addition of Heparin which formed a coating around the liposomes, caused a strong localization of fluorescence within the epidermis. For full thickness skin, mechanical cross sections of skin were made and optical sections were recorded parallel to the plane of cut. Phospholipid penetrated and was distributed fairly homogeneously in the lower dermis layers within 30 min of application regardless of liposome composition and the prese...Continue Reading

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Citations

Mar 17, 2004·Advanced Drug Delivery Reviews·Gregor Cevc
May 20, 2003·International Journal of Pharmaceutics·Claudia Valenta, Michaela Janisch
Apr 2, 2004·Biological & Pharmaceutical Bulletin·Yasutami ShigetaTaketoshi Makino
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Yasutami ShigetaTaketoshi Makino
Aug 2, 2011·Archives of Dermatological Research·Maria Bernadete Riemma Pierre, Irina Dos Santos Miranda Costa
Nov 7, 2014·Therapeutic Delivery·Chia-Lang FangJia-You Fang
Oct 15, 2014·Drug Development and Industrial Pharmacy·Hadi ValizadehParvin Zakeri-Milani
Sep 17, 2010·Journal of Pharmaceutical Sciences·Shuhua Bai, Fakhrul Ahsan
Jul 2, 2011·Journal of Pharmaceutical Sciences·Qing WangKyriakos D Papadopoulos
Sep 2, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dolores C CarrerLuis A Bagatolli
Oct 24, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Denise-Silvia MahrhauserClaudia Valenta
Aug 21, 2008·International Journal of Cosmetic Science·M PhetdeeJ Viyoch
Feb 15, 2005·International Journal of Pharmaceutics·Alma FocoJulijana Kristl
Jan 10, 2003·Journal of Liposome Research·Khalid AhmedMalcolm N Jones
Feb 1, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Masoumeh Ghafarzadeh, Ali Eatemadi
Sep 22, 2007·The Journal of Pharmacy and Pharmacology·Kevin B ItaJeanetta du Plessis
Nov 10, 2021·Pharmaceutical Development and Technology·Ghada M El-Zaafarany, Maha Nasr

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