PMID: 8946020Nov 4, 1996Paper

Interaction of low-dose irradiation with subsequent mutagenic treatment: role of mitotic delay

Mutation Research
B SaloneG Olivieri

Abstract

Experiments were carried out with human lymphocytes to test whether there was any relation between the changes that conditioning treatment can produce in cell progression or in mitotic delay induced by the challenge dose and the presence of an 'adaptive response' (AR). In experiments in which the cells were successively fixed after the challenge dose, the interaction between conditioning treatment and challenge was of the same sign for all the fixation times: therefore it is likely that modifications of the cytogenetic damage in primed cells is not a mere reflection of stage sensitivity. In experiments in which using 1 Gy as conditioning treatment we induced a drastic extension of G2, we did not observe any AR; therefore, even if conditioning treatment can induce modifications in the cell-cycle phases before and/or after challenge, there is probably no link between these modifications and the presence of an AR.

References

Feb 1, 1992·Mutation Research·J D Shadley, G Q Dai
Nov 1, 1991·Mutation Research·S Z Aghamohammadi, J R Savage
Mar 1, 1989·Mutation Research·A Bosi, G Olivieri
Mar 1, 1989·Mutation Research·K SankaranarayananA T Natarajan

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Citations

Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Octávia Monteiro GilJosé Rueff
Nov 30, 2006·Radiation and Environmental Biophysics·Soile Tapio, Vesna Jacob
Mar 14, 2009·Tsitologiia·I I PelevinaA M Serebrianyĭ
Jul 8, 2009·Radiation Research·Anna SanninoMaria Rosaria Scarfì
Sep 29, 2005·Radiation Research·Patricia CramersJos C S Kleinjans
Oct 2, 1998·Human & Experimental Toxicology·D A BoothmanM S Mendonca

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