Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring.

Psychological Medicine
M Camille HoffmanRobert Freedman

Abstract

This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from the mother activates α7-nicotinic acetylcholine receptors on fetal cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade of their cannabinoid-1(CB1) receptors. Marijuana use was assessed during pregnancy from women who later brought their newborns for study. Mothers were informed about choline and other nutrients, but not specifically for marijuana use. Maternal serum choline was measured at 16 weeks gestation. Marijuana use for the first 10 weeks gestation or more by 15% of mothers decreased newborns' inhibition of evoked potentials to repeated sounds (d' = 0.55, p < 0.05). This effect was ameliorated if women had higher gestational choline (rs = -0.50, p = 0.011). At 3 months of age, children whose mothers continued marijuana use through their 10th gestational week or more had poorer self-regulation (d' = -0.79, p < 0.05). This effect was also ameliorated if mothers had higher gestational choline (rs = 0.54, p = 0.013). Maternal choline levels correlated with the children's improved duration of attention, cuddliness, and bondi...Continue Reading

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Citations

Dec 4, 2019·Psychological Medicine·Sharon K HunterAmanda J Law
Feb 8, 2021·Metabolomics : Official Journal of the Metabolomic Society·Nipun SainiSusan M Smith
Oct 17, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Robert FreedmanM Camille Hoffman

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