Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75

Gene
S IshikawaT Moriuchi

Abstract

AIE-75 is a protein identified as an autoantigen in patients with autoimmune enteropathy and as a colon cancer-related antigen. It has recently been assigned to be a causative gene for Usher type 1C congenital syndromic hearing loss. The novel protein has three PSD-95/Dlg/ZO-1 (PDZ) protein-protein interaction domains and is therefore implicated to function as a molecular anchor or sorter. We have identified a novel protein that binds to AIE-75 by yeast two-hybrid screening. The protein has a high homology to the tumor suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. Since the MCC1 does not bind to AIE-75 and the MCC2 displays different expression patterns in various organs compared to MCC1, they appear to play distinct roles in cells. The MCC2 gene is located on chromosome 19p13 in the vicinity of APCL gene, while MCC1 maps near to APC tumor suppressor gene. Because of negative expression of MCC2 in a panel of cancer cell-lines compared to the corresponding normal tissues, we suggest that further study is necessary to investigate a possible role of MCC2 as a tumor suppressor.

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Citations

Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Philip M ShermanErnest Cutz
Mar 24, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Shashirekha ShettyBirgitte Roland
Oct 6, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Anne M JohnstonL Jorge Góñez
Oct 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Teddy YoungN Ray Dunn
Sep 22, 2006·Human Molecular Genetics·Hannie KremerRonald Roepman
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Lars M MarthinsenJan Ejderhamn

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