Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

The American Journal of Clinical Nutrition
Yiyi MaRozenn N Lemaitre

Abstract

DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression. We aimed to explore whether the gene-by-diet interactions on blood lipids act through DNA methylation. We selected 7 SNPs on the basis of predicted relations in fatty acids, methylation, and lipids. We conducted a meta-analysis and a methylation and mediation analysis with the use of data from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium and the ENCODE (Encyclopedia of DNA Elements) consortium. On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (β = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (β = 3.87 mg/dL, P = 5.62 × 10(21)). The difference in HDL cholesterol associated with higher circulating EPA was dependent on genotypes at rs2246293, and it was greater for each additional C allele (β = 1.69 mg/dL, P = 0.006). In the GOLDN (Genetics of Lipid Lowering Drugs and Diet Network) study, higher ABCA1 promoter cg14019050 methylation was associated with more C alleles at rs2246293 (β = 8.84%...Continue Reading

References

Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Jun 1, 2002·Molecular Endocrinology·Michael PodvinecUrs A Meyer
Aug 7, 2002·The Journal of Nutrition·Chunming DongPascal J Goldschmidt-Clermont
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Feb 27, 2007·Science·Asaf Hellman, Andrew Chess
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Oct 3, 2007·PLoS Genetics·Jeffrey T Leek, John D Storey
Jan 9, 2008·American Journal of Human Genetics·Chris WallacePatricia B Munroe
Jan 15, 2008·Nature Genetics·Cristen J WillerGonçalo R Abecasis
Feb 12, 2008·Lancet·Manjinder S SandhuVincent Mooser
Jul 5, 2008·Nature·Alexander MeissnerEric S Lander
Dec 9, 2008·Nature Genetics·Sekar KathiresanL Adrienne Cupples
Dec 9, 2008·Nature Genetics·Yurii S AulchenkoUNKNOWN ENGAGE Consortium
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael T McCabePaula M Vertino
Mar 11, 2010·American Journal of Human Genetics·Dandan ZhangChunyu Liu
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Mar 29, 2011·Nature·Jason ErnstBradley E Bernstein
Oct 4, 2011·Nature Genetics·Florian LienertDirk Schübeler
Mar 16, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Simon-Pierre GuayLuigi Bouchard
Aug 19, 2014·Nature Neuroscience·Philip L De JagerDavid A Bennett
Jul 8, 2015·Nature Reviews. Endocrinology·Claire Greenhill

❮ Previous
Next ❯

Citations

Dec 7, 2016·The Proceedings of the Nutrition Society·Yiyi Ma, Jose M Ordovas
Nov 15, 2017·Current Opinion in Lipidology·Laurence D ParnellChao-Qiang Lai
Mar 11, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paolo VineisSoterios Kyrtopoulos
Jan 14, 2020·Annual Review of Food Science and Technology·Steven H Zeisel
Aug 4, 2020·Culture, Health & Sexuality·Roanna LoboLinda A Selvey
Apr 30, 2017·Clinical Epigenetics·Bénédicte L TremblayMarie-Claude Vohl
Aug 13, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Ryosuke FujiiKoji Suzuki
Sep 2, 2021·Current Atherosclerosis Reports·Alana C JonesDonna K Arnett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.