PMID: 6112734Jan 1, 1980Paper

Interaction of MIF-I or alpha-MSH with D-amphetamine or chlorpromazine on thermoregulation and motor activity of rats maintained at different ambient temperatures

Peptides
S Yehuda, A J Kastin

Abstract

Administration of several doses of MIF-I or alpha-MSH did not modify colonic temperature or the level of motor activity of rats in ambient temperatures of 4 degree or 20 degrees C. However, the thermoregulatory but not motor effects of the interaction between MIF-I or alpha-MSH with d-amphetamine were dependent upon ambient temperature. At 4 degree C, 1.0 mg/kg of both peptides enhanced the d-amphetamine-induced hypothermia, but at 20 degrees C both peptides blocked the hyperthermic effects of d-amphetamine. The hypothermic effect of chlorpromazine (CPZ) at 4 degree C and 20 degrees C was blocked by 1.0 mg/kg MIF-I but not by 1.0 mg/kg alpha-MSH. No linear dose response relationships between various doses of MIF-I or alpha-MSH and thermal responses were found. Administration of melanin or the use of hypophysectomized rats did not alter the significant interactions observed after peripheral injections.

References

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Jan 1, 1979·Neuroscience·J Bligh
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Jan 8, 2013·Molecular Cell·Reut ShalgiChristopher B Burge

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Citations

Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·S YehudaD H Coy
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·A J KastinR H Ehrensing
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·A J KastinD H Coy
May 1, 1989·Pharmacology, Biochemistry, and Behavior·A J KastinD S Schwartzenburg
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·L H Raible, D Knickerbocker
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S Yehuda, A J Kastin
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1983·Pharmacology & Therapeutics·W G Clark, J M Lipton
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin

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