PMID: 8968188Dec 1, 1996Paper

Interaction of morphine and clonidine on gastrointestinal transit in mice

Anesthesiology
Margarita M PuigW Warner

Abstract

Combinations of drugs are frequently used to achieve effective analgesia while minimizing side effects. Although the analgesic effects of morphine and clonidine seem to be synergistic, few studies have investigated other effects. Their role in inhibiting gastrointestinal transit was evaluated using different methods of analysis. Percentage inhibition of transit induced by morphine, clonidine, or their combination was measured in mice that had been given an intragastric charcoal meal. Dose-response curves were obtained for each drug individually; for morphine:clonidine at 1:3, 1:1, and 1:0.33 ratios; and for morphine in the presence of 0.0138 mg/kg clonidine. The interaction was evaluated by isobolograms, combination indexes, and fixed-dose analysis. Each drug and their combinations inhibited transit in a dose-related manner. Combinations of morphine and clonidine produced interaction that depended on the ratio and level of response. The interaction analyzed by isobolograms and combination indexes showed that combinations in 1:1 and 1:3 proportions were synergistic at the median effective doses or less and were antagonistic at larger doses. Fixed-dose analysis using different ratios showed similar results. The effects of the com...Continue Reading

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Citations

Jun 22, 2005·International Journal of Colorectal Disease·Michel BouchouchaMichel Arsac
May 29, 1998·Brain Research. Molecular Brain Research·S RoyH H Loh
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Apr 4, 1998·Journal of Clinical Anesthesia·J VallèsM M Puig
Nov 20, 1997·Anesthesiology·T Asai, W W Mapleson
Mar 10, 2009·Fundamental & Clinical Pharmacology·H F MirandaJ C Prieto
Nov 23, 2005·European Journal of Pain : EJP·Christian DürstelerMargarita M Puig
Apr 28, 2017·PloS One·Sarah K SharmanDarren D Browning

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