Interaction of nitric oxide with tetrathiolato iron(II) complexes: relevance to the reaction pathways of iron nitrosyls in sulfur-rich biological coordination environments

Journal of the American Chemical Society
Todd C HarropStephen J Lippard

Abstract

The mechanism of formation of dinitrosyl iron complexes (DNICs) coordinated by cysteine residues at iron-sulfur protein sites has received little attention in the chemical literature. As a logical first step toward elucidating this mechanism and characterizing new iron-nitrosyl intermediates, we investigated the interaction of NO (g) and NO+ with iron-sulfur complexes chosen to mimic sulfur-rich iron sites in biology. The reaction of NO (g) with [Fe(StBu)4]2- cleanly affords the mononitrosyl complex, [Fe(StBu)3(NO)]- (1), a previously unknown species evoked in this chemistry. Reaction of [Fe(StBu)4]2- with NO derivatives, such as NO+, yields the corresponding dinitrosyl S-bridged Roussin red ester [Fe2(mu-StBu)2(NO)4] (2). The nitrosyl complexes 1 and 2 can chemically convert to the DNIC, [Fe(StBu)2(NO)2]- (3). The results should aid in the spectroscopic identification and elucidation of reaction pathways for the nitrosylation of iron in biologically related sulfur-rich coordination environments.

References

Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Apr 11, 2002·Chemical Reviews·Anthony R Butler, Ian L Megson
Jul 3, 2002·The EMBO Journal·Hugo Cruz-RamosRobert K Poole
Feb 12, 2004·Chemical Reviews·J A McCleverty
Jan 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrzej WeichselWilliam R Montfort

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Citations

Sep 11, 2012·Inorganic Chemistry·Camly T Tran, Eunsuk Kim
Jul 30, 2010·Inorganic Chemistry·Zachary J TonzetichStephen J Lippard
Dec 8, 2010·Journal of the American Chemical Society·Christine E TinbergStephen J Lippard
Aug 15, 2008·Journal of the American Chemical Society·Matthew T OlsenScott R Wilson
Nov 1, 2011·Chemistry & Biology·Andrew G Tennyson, Stephen J Lippard
Jul 14, 2010·Chemistry : a European Journal·Kathrin H HopmannAbhik Ghosh
Feb 20, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Lei YangRobert P Houser
May 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Szu-Liang ChoTsai-Te Lu
Jan 24, 2012·Chemistry : a European Journal·Feng-Chun LoSteve S-F Yu
Jul 6, 2013·Biopolymers·Jaimeen D Majmudar, Brent R Martin
Jun 7, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Hanna LewandowskaMarcin Kruszewski
Jan 8, 2014·Chemical Communications : Chem Comm·Atsutoshi YokoyamaWonwoo Nam
Sep 10, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniel B GrabarczykKylie A Vincent
May 16, 2013·Chemical Communications : Chem Comm·Jessica FitzpatrickEunsuk Kim
Jun 12, 2010·The Journal of Physical Chemistry. B·Jeanet ConradieAbhik Ghosh
Oct 22, 2008·Journal of the American Chemical Society·Andrew G TennysonStephen J Lippard
Oct 23, 2008·Journal of the American Chemical Society·Todd C HarropStephen J Lippard
Sep 27, 2006·Inorganic Chemistry·David P KleinLawrence Que
Jan 25, 2011·Journal of Chemical Theory and Computation·Arteum D BochevarovStephen J Lippard
Aug 11, 2021·Chemical Communications : Chem Comm·Nabhendu PalAmit Majumdar
Dec 6, 2014·Journal of the American Chemical Society·José Clayston Melo PereiraPeter C Ford
Jan 20, 2011·Inorganic Chemistry·Zachary J TonzetichStephen J Lippard
Jan 22, 2011·Inorganic Chemistry·Michael J ZdillaSonny C Lee

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