Interaction of nonsteroidal anti-inflammatory drugs with membranes: in vitro assessment and relevance for their biological actions

Progress in Lipid Research
Catarina Pereira-LeiteSalette Reis

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world due to their anti-inflammatory, analgesic and antipyretic properties. Nevertheless, the consumption of these drugs is still associated with the occurrence of a wide spectrum of adverse effects. Regarding the major role of membranes in cellular events, the hypothesis that the biological actions of NSAIDs may be related to their effect at the membrane level has triggered the in vitro assessment of NSAIDs-membrane interactions. The use of membrane mimetic models, cell cultures, a wide range of experimental techniques and molecular dynamics simulations has been providing significant information about drugs partition and location within membranes and also about their effect on diverse membrane properties. These studies have indeed been providing evidences that the effect of NSAIDs at membrane level may be an additional mechanism of action and toxicity of NSAIDs. In fact, the pharmacokinetic properties of NSAIDs are closely related to the ability of these drugs to interact and overcome biological membranes. Moreover, the therapeutic actions of NSAIDs may also result from the indirect inhibition of cyclooxygenase due to the disturbing eff...Continue Reading

References

Feb 18, 1972·Science·S J Singer, G L Nicolson
Mar 18, 1983·Science·L M LichtenbergerB A Hills
Nov 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J R Vane, R M Botting
Aug 31, 2000·Annual Review of Biochemistry·W L SmithR M Garavito
Nov 18, 2000·British Journal of Pharmacology·F E MingattoC Curti
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A V SarmaM LaBerge
Mar 20, 2002·Current Topics in Medicinal Chemistry·A Avdeef
Jul 26, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Urs A Boelsterli
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Fábio E MingattoAntonio C Santos
Jan 4, 2003·Hypertension·Pablo V EscribáValentina Ruiz-Gutiérrez
Aug 5, 2003·Analytical and Bioanalytical Chemistry·Helena FerreiraSalette Reis
Mar 24, 2004·Biochemical Pharmacology·Jayasree BasivireddyKunissery A Balasubramanian
Aug 20, 2004·Pharmacological Reviews·Daniel L SimmonsTimothy Hla
Sep 24, 2004·Biochemical and Biophysical Research Communications·Wataru TomisatoTohru Mizushima
Nov 24, 2004·Chemistry and Physics of Lipids·I KyrikouT Mavromoustakos
Mar 16, 2005·Analytical Biochemistry·Helena FerreiraSalette Reis
Apr 29, 2005·Journal of Pharmaceutical Sciences·Helena FerreiraSalette Reis
May 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Hirak Chakraborty, Munna Sarkar
May 24, 2005·Biophysical Chemistry·Hirak Chakraborty, Munna Sarkar
Jun 29, 2005·Analytical and Bioanalytical Chemistry·Helena FerreiraSalette Reis
Aug 9, 2005·Journal of Colloid and Interface Science·Hirak Chakraborty, Munna Sarkar
Sep 27, 2005·Chemistry and Physics of Lipids·Hirak ChakrabortyMunna Sarkar
Dec 6, 2005·Trends in Molecular Medicine·Pablo V Escribá
Aug 5, 2006·Seminars in Arthritis and Rheumatism·Stephen B Miller
Oct 13, 2006·The Journal of Pharmacy and Pharmacology·Majella E Lane, Mi-Jeong Kim
Oct 17, 2006·Basic & Clinical Pharmacology & Toxicology·Samara LeiteAntonio Cardozo dos Santos
Feb 20, 2007·Current Topics in Medicinal Chemistry·Subhash P KhanapureL Gordon Letts
Feb 20, 2007·Biochimica Et Biophysica Acta·Hirak ChakrabortyMunna Sarkar
Mar 1, 2007·Arthritis and Rheumatism·Tannin A SchmidtRobert L Sah
Jul 20, 2007·The Journal of Biological Chemistry·Irina TreedeRobert Ehehalt
Jul 31, 2007·Analytica Chimica Acta·Marlene LúcioSalette Reis
Nov 9, 2007·Journal of Pharmaceutical Sciences·Célia SousaSalette Reis

❮ Previous
Next ❯

Citations

Dec 20, 2014·European Journal of Immunology·Federico Díaz-González, Francisco Sánchez-Madrid
Aug 5, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Claire R Hatty, Richard B Banati
Dec 6, 2014·Biochimica Et Biophysica Acta·Richard J AlsopMaikel C Rheinstädter
Sep 3, 2016·Pharmacological Reports : PR·Hugo F MirandaJuan Carlos Prieto
Dec 23, 2016·Medicinal Research Reviews·Catarina Pereira-LeiteSalette Reis
Jan 7, 2017·Physical Chemistry Chemical Physics : PCCP·V K SharmaM Tyagi
Jan 15, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Natalia WilkoszMariusz Kepczynski
May 18, 2018·Physical Chemistry Chemical Physics : PCCP·Catarina Pereira-LeiteSalette Reis
Sep 6, 2019·Physical Chemistry Chemical Physics : PCCP·V K SharmaE Mamontov
Oct 2, 2020·Biomolecules·Jan KremkowHolger A Scheidt
Jan 30, 2016·The Journal of Veterinary Medical Science·Tülay BakirelUtku Bakirel
Feb 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Catarina Pereira-LeiteSalette Reis
Nov 2, 2019·Biochimica Et Biophysica Acta. Biomembranes·V K SharmaM Tyagi
Jan 2, 2021·Membranes·Catarina Pereira-LeiteSalette Reis
Apr 8, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Megan WoodSunghee Lee
Apr 11, 2021·Chemistry and Physics of Lipids·Guilherme Nuñez JaroqueLuciano Caseli
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sivaramakrishnan RamaduraiTia E Keyes
Feb 8, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Veerendra Kumar SharmaRamaprosad Mukhopadhyay
Oct 24, 2018·The Journal of Physical Chemistry. B·P S DubeyR Mukhopadhyay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Bulletin of the Hospital for Joint Diseases Orthopaedic Institute
S Abramson
Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Alexa Simon Meara, Lee S Simon
La Revue de médecine interne
P VergneR Trèves
© 2021 Meta ULC. All rights reserved