Interaction of oxovanadium(IV)-salphen complexes with bovine serum albumin and their cytotoxicity against cancer

Dalton Transactions : an International Journal of Inorganic Chemistry
Velusamy Gomathi SankareswariSeenivasan Rajagopal

Abstract

Vanadyl compounds of clinical significance are recommended as drugs against diseases such as tuberculosis, diabetes, cancer, etc. In order to check the potential of the salphen ligands and oxovanadium(IV)-salphen complexes as drugs their binding with bovine serum albumin (BSA) is investigated. The binding constants measured at pH 7.4 using UV-vis absorption and fluorescence techniques are in the range of 10(3)-10(5) M(-1). The quenching of the fluorescence of BSA and appearance of enhanced luminescence of the salphen ligand/vanadium(IV) complex at the increased [quencher] show efficient FRET from the protein to the quencher and the distance of energy transfer estimated using Forster's theory is in the range of 1.4-3.5 nm. Molecular docking studies (DFT) utilizing oxovanadium(IV)-salphen derivatives show strong binding with BSA and give insight into the binding modes, interaction pattern and stability of synthesized complexes in the target site. The cytotoxicity study shows the ability of these V(IV) complexes to inhibit the growth of AGS gastric cell lines.

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Citations

Dec 25, 2015·Inorganic Chemistry·Lilia ReytmanEdit Y Tshuva
Mar 19, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·N Rajendiran, J Thulasidhasan
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Sep 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashaparna Mondal, Priyankar Paira
Dec 21, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jebiti HaribabuRamasamy Karvembu
Jan 29, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Nilmadhab RoyAnbalagan Moorthy
Jul 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Binoy KarPriyankar Paira

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