Interaction of particle-bound [125I]C3b, the third component of complement, with specific receptors on human B-lymphoblastoid cells (Raji)

Immunology Letters
R Frade, J L Strominger

Abstract

Taking advantage of the high density of the complex formed between the C3b receptor on cultured B-lymphoblastoid cells and particle-bound C3b, some properties of their interaction were studied. The process had an apparent dissociation constant equal to 10(-7) M. Thus particle-bound C3b has a higher affinity for C3b receptor than soluble C3b. Moreover, analysis of dissociation rate of particle-bound C3b-C3b receptor complexes suggested that a cooperative effect was induced at the cell surface by particle-bound C3b but not by soluble C3b. The most suitable explanations of these data are discussed.

References

May 21, 1976·Biochimica Et Biophysica Acta·S Jacobs, P Cuatrecasas
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S K Law, R P Levine
Jul 1, 1975·The Journal of Experimental Medicine·M P Dierich, R A Reisfeld
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·V A BokischH J Mūller-Eberhard
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Nov 1, 1968·The Journal of Experimental Medicine·W H Lay, V Nussenzweig
Nov 1, 1973·Biochemical and Biophysical Research Communications·P de MeytsM A Lesniak
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G R GuntherG M Edelman
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H R PettyH M McConnell

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