PMID: 9530863Apr 8, 1998Paper

Interaction of PCB congeners and 2,3,7,8-TCDD in the rat liver: an electron microscope study

Journal of Submicroscopic Cytology and Pathology
B J ConnellI Chu

Abstract

Polyhalogenated aromatic compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins continue to be environmental contaminants because of their bioaccumulation in the food chain and resistance to biodegradation. This study was undertaken to determine if WHO-IPCS PCB congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) individually or their coadministration in rats produced morphological alterations in the liver. Groups (N = 5) of female Sprague Dawley rats received TCDD (0, 2.5, 25, 250, 1,000 ng/kg bw/day) or PCB (0, 2, 20 micrograms/kg bw/day) either alone, or each dose of PCB coadministered with that of TCDD. The test substances were dissolved in corn oil and given by gavage at 0.2 ml/100 g bw/day for 28 days. At the end of the experiment the rats were killed and liver samples were prepared for transmission electron microscopy. Electron micrographs of the liver from animals of the control groups revealed characteristic normal hepatocyte architecture. An increase in smooth endoplasmic reticulum (SER) profiles and a corresponding decrease in the profiles of rough endoplasmic reticulum (RER) proportional to the increased doses of the compounds was revealed in the micrographs. Coadministration of ...Continue Reading

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.