Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus

Experimental Dermatology
C NakashimaKenji Kabashima

Abstract

Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the pathogenesis of neurogenic inflammation, pain and pruritus. Emerging evidence shows that these cells are the main source of pruritogens such as histamine, neuropeptides and cytokines, which are potential new therapeutic targets for drug development in chronic pruritus. For instance, many Th2 cytokines including interleukin (IL)-4, 13 and 31 have been recognized as some of the most promising targets for the treatment of chronic pruritus in AD. In this review, we highlight the link between these three immune cell subsets and peripheral nerves, with emphasis on the development of chronic pruritus such as AD. We present cytokines and receptors of these three immune cells and peripheral nerves, and discuss the therapeutic potential of targeting these neuro-immunological processes.

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Citations

May 8, 2020·Cells·Md Abdul AlimGunnar Pejler
Dec 20, 2019·Experimental Dermatology·Sonja Ständer, Gil Yosipovitch
Apr 23, 2020·Allergy·Cezmi A AkdisOscar Palomares
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Feb 11, 2021·Experimental Dermatology·Scott X Atwood, Maksim V Plikus
Jan 10, 2021·International Journal of Molecular Sciences·Yu SawadaMotonobu Nakamura
Mar 9, 2021·Frontiers in Medicine·Aylin RuppensteinUlrike Raap
Apr 4, 2021·International Journal of Molecular Sciences·Mika Yamanaka-TakaichiDaisuke Tsuruta
May 1, 2021·International Journal of Molecular Sciences·Martin VossAnne Dudeck
May 8, 2021·Neuroscience Letters·Megan L UhelskiPatrick M Dougherty
Jun 8, 2021·Seminars in Immunopathology·Susanne Radonjic-HoesliDagmar Simon
Jun 3, 2021·International Journal of Molecular Sciences·Yu SawadaMotonobu Nakamura
Jun 10, 2021·Expert Review of Clinical Immunology·Celina DubinEmma Guttman-Yassky

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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