Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.

The Journal of Biological Chemistry
Parimal MisraJanardan K Reddy

Abstract

PIMT (PRIP-interacting protein with methyltransferase domain), an RNA-binding protein with a methyltransferase domain capable of binding S-adenosylmethionine, has been shown previously to interact with nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR)-interacting protein) and enhance its coactivator function. We now report that PIMT strongly interacts with transcriptional coactivators, CBP, p300, and PBP but not with SRC-1 and PGC-1alpha under in vitro and in vivo conditions. The PIMT binding sites on CBP and p300 are located in the cysteine-histidine-rich C/H1 and C/H3 domains, and the PIMT binding site on PBP is in the region encompassing amino acids 1101-1560. The N-terminal of PIMT (residues 1-369) containing the RNA binding domain interacts with both C/H1 and C/H3 domains of CBP and p300 and with the C-terminal portion of PBP that encompasses amino acids 1371-1560. The C-terminal of PIMT (residues 611-852), which binds S-adenosyl-l-methionine, interacts respectively with the C/H3 domain of CBP/p300 and with a region encompassing amino acids 1101-1370 of PBP. Immunoprecipitation data showed that PIMT forms a complex in vivo with CBP, p300, PBP, and PRIP. PIMT appeared to be co-localized in...Continue Reading

References

Oct 28, 1993·Nature·J C ChriviaR H Goodman
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Sep 20, 1997·Nature·T E SpencerB W O'Malley
Jan 31, 1998·The Journal of Biological Chemistry·P DowellM Leid
Feb 21, 1998·Science·R KurokawaC K Glass
Jun 17, 1998·Genes & Development·J C BlancoK Ozato
Sep 30, 1998·Progress in Nucleic Acid Research and Molecular Biology·J D Gary, S Clarke
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·C QiJ K Reddy
Jun 26, 1999·Science·D ChenM R Stallcup
Feb 22, 2000·The Journal of Biological Chemistry·F CairaJ A Gustafsson
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L KoW W Chin
Jun 6, 2000·Trends in Biochemical Sciences·S Malik, R G Roeder
Mar 30, 2001·The Journal of Biological Chemistry·N Vo, R H Goodman
Jul 19, 2001·Genes & Development·E P LeiP A Silver
Jul 19, 2001·The Journal of Biological Chemistry·M G Rosenfeld, C K Glass
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y ZhuJ K Reddy
Feb 2, 2002·Science·Ali H Brivanlou, James E Darnell

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Citations

Mar 29, 2006·Cellular and Molecular Life Sciences : CMLS·K Pahan
Mar 30, 2004·Biochemical and Biophysical Research Communications·Tao HongTakashi Ito
Feb 26, 2004·Gene·Per AntonsonJan-Ake Gustafsson
Aug 5, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S W van den BergJ M A Boer
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Venkat S R K Yedavalli, Kuan-Teh Jeang
Jan 30, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Simon M PlummerClifford R Elcombe
Jan 31, 2003·Molecular and Cellular Biology·Per AntonsonJan-Ake Gustafsson
Sep 4, 2010·PPAR Research·Navin ViswakarmaJanardan K Reddy
Feb 22, 2012·Journal of Nucleic Acids·Tae Suk Ro-Choi, Yong Chun Choi
Aug 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yuzhi JiaJanardan K Reddy
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sailesh SurapureddiJanardan K Reddy
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Liang BaiJanardan K Reddy
Sep 18, 2012·Mechanisms of Development·Yuzhi JiaJanardan K Reddy
Dec 30, 2003·Genes, Chromosomes & Cancer·Andrea ZatkovaKatharina Wimmer
Nov 25, 2004·Endocrine Reviews·Muktar A Mahajan, Herbert H Samuels
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Parimal MisraRajagopalan Ramanujam
Aug 17, 2004·The Journal of Biological Chemistry·Karthikeyan NarayananAnne George
May 13, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Miriam WeberRalf Lösel
May 19, 2018·International Journal of Molecular Sciences·Yuzhi JiaJanardan K Reddy
Nov 30, 2019·Frontiers in Pharmacology·Yiyan WangRen-Shan Ge
Apr 10, 2019·Polymers·Barbara LapinskaMonika Lukomska-Szymanska
Dec 19, 2019·Frontiers in Plant Science·Carolina ColonoSilvina C Pessino
Aug 12, 2009·Molecular Biology Reports·Praveen BawankarSwati Patankar
Jun 28, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·E Ilker OzayLisa M Minter
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