PMID: 2117030Aug 1, 1990Paper

Interaction of platelet-activating factor with interferon-gamma in the stimulation of interleukin-1 production by human monocytes

The Journal of Allergy and Clinical Immunology
R Barthelson, F Valone

Abstract

Platelet-activating factor (PAF) produces both early and late inflammatory responses in vivo. The late and persistent responses to PAF may result from the production of cytokines, such as interleukin-1 (IL-1). The effects of PAF on IL-1 release by human monocytes were studied with PAF alone and in combination with interferon-gamma. These studies involved the use of D10.G4.1 cells in a proliferation assay to determine the actual concentration of active IL-1 in monocyte supernatant and pellet fractions. These studies confirmed that PAF stimulates IL-1 release at two different ranges of PAF concentrations, 100 fM to 1 pM and 100 pM to 1 nM. PAF inhibited IL-1 release at 1 or 10 pM. PAF effects on IL-1 release were specific to the form of PAF that is biologically active in most system; (S)-PAF and lyso-PAF had no effect. When monocytes were incubated with both PAF and interferon-gamma, IL-1 release was greatly stimulated at the same two ranges of PAF concentrations, 100 fM to 1 pM and 100 pM to 1 nM of PAF. PAF and interferon-gamma interacted synergistically to enhance significantly the release of IL-1.

References

Feb 1, 1990·Current Opinion in Oncology
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Citations

May 5, 1993·Journal of Immunological Methods·R A Barthelson
Jan 1, 1992·Mediators of Inflammation·M Rola-Pleszczynski, J Stankova
Dec 31, 1991·Biochemical and Biophysical Research Communications·E MüllerM Rola-Pleszczynski
Mar 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S P Travis, D P Jewell
Apr 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O FukutomiT Orii

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