Interaction of platelet fc and complement receptors with circulating immune complexes involving the AB0 system

Vox Sanguinis
Joanna M HealNeil Blumberg

Abstract

When platelets that are AB0-nonidentical are transfused, circulating immune complexes (CIC) are formed. In the present study we examined the ability of polyclonal antibodies to two C1q receptors on platelets, cC1q-R and gC1q-R, and a monoclonal IgG Fc gamma RII (CD32) antibody directed against the platelet Fc receptor to inhibit the uptake of CIC involving the AB0 blood group system by normal platelets. Four types of immune complexes of varying purity were made in vitro. In addition serum from 5 refractory group A patients who had demonstrable AB0 CIC, 5 patients who had received only AB0-identical platelets and had no AB0 CIC and 6 normal donors were evaluated. After exposure of normal platelets to serum of patients with demonstrable AB0 CIC there were increased levels of platelet-associated IgG. This binding was partially inhibited by preincubation of the platelets with either anti-cC1q-R (3/5 patients), gC1q-R (3/5 patients) or IgG Fc gamma RII in 4/5 patients. However, the pattern of inhibition by the three antibodies was variable. Using the artificial immune complexes a more consistent pattern was obtained. The binding of four types of artificial immune complexes to platelets was reduced by 67-99% after preincubation of th...Continue Reading

References

Jan 1, 1992·British Journal of Haematology·J M HealN Blumberg
Apr 1, 1992·Clinical Immunology and Immunopathology·E I Peerschke, B Ghebrehiwet
Mar 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L A Hebert
Aug 1, 1986·The Journal of Clinical Investigation·G H YuJ P Atkinson
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J L ColeJ P Atkinson
Nov 1, 1993·British Journal of Haematology·J M HealN Blumberg

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Citations

Jun 9, 2004·Blood Reviews·Joanna Mary Heal, Neil Blumberg
Dec 22, 1999·Transfusion·J M Heal, N Blumberg
Sep 28, 2007·Current Opinion in Hematology·Ralph R Vassallo
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Peter Hellstern
Feb 24, 2015·Frontiers in Immunology·Moritz StollaNeil Blumberg
Mar 23, 2017·Vox Sanguinis·R L BartyN M Heddle

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