Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis: Role of transplanted endothelial progenitor cells and platelet microparticles

Biology of the Cell
Nicoleta AlexandruAdriana Georgescu

Abstract

Recent studies suggest that endothelial progenitor cells (EPCs) and platelets have an important role in repair following vascular injury. Although evidence suggest that platelets are essential in EPC attracting, homing and differentiation to the injury site; however, the platelet effects on EPC function in atherosclerosis have received less attention. In this context, we followed the consequences of circulating EPCs and platelet microparticles (PMPs) administration on platelet-EPC interaction in atherosclerosis and the involved mechanisms. The experiments were performed on Golden Syrian hamsters divided in five equal groups: control (C), hypertensive-hypercholesterolemic (HH), HH treated with EPCs (HH-EPCs) or PMPs (HH-PMPs) and HH treated with EPCs and PMPs (HH-EPCs-PMPs). Compared with C group, EPCs isolated from HH and HH-PMPs groups presented a reduction of endothelial nitric oxide synthase and vascular endothelial growth factor expressions and an increase in thrombospondin-1 expression and inflammatory molecule secretion: interleukin 8 (IL)-8, myeloperoxidase (MPO) and plasminogen activator inhibitor-1 (PAI-1). EPC administration had beneficial effects, the obtained results being similar with those from the C group, while ...Continue Reading

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Citations

Mar 16, 2016·Atherosclerosis·Zhi-Ting WangYan-Wei Hu
Jul 4, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Zhibo ChenXu Zhang
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Dec 18, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Elizabeth W J KerrisRobert J Freishtat
May 10, 2019·Frontiers in Pharmacology·Nicoleta AlexandruAdriana Georgescu
Dec 7, 2018·Cardiovascular Toxicology·Habib HaybarNajmaldin Saki
Oct 24, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Zhenya FangMeihua Zhang

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