Interaction of plectin and intermediate filaments

Journal of Dermatological Science
Tadashi KarashimaTakashi Hashimoto

Abstract

Plectin, a member of the plakin family proteins, is a high molecular weight protein that is ubiquitously expressed. It acts as a cytolinker for the three major components of the cyotoskeleton, namely actin microfilaments, microtubules and intermediate filaments. The aim of our experiments was to identify new binding sites for intermediate filaments on plectin and to specify these sites. We introduced truncated forms of plectin into several cell lines and observe interaction between plectin and intermediate filaments. We found that a linker region in the COOH-terminal end of plectin was required for the association of the protein with intermediate filaments. In addition, we also demonstrated that a serine residue at position 4645 of plectin may have a role on binding of plectin to intermediate filaments. A linker region in the COOH-terminal end and serine residue at position 4645 may be important for the binding of plectin to intermediate filaments.

References

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Citations

Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kristin SeltmannThomas M Magin
Jun 19, 2014·The Journal of Investigative Dermatology·Jamal-Eddine BouameurLuca Borradori
Jun 14, 2013·Cytoskeleton·Mainak GuharoyPeter Tompa
Jan 8, 2013·The British Journal of Dermatology·A CharlesworthG Meneguzzi
Mar 18, 2015·Journal of Medical Virology·Alberta Lucchese
Jul 13, 2016·Journal of Cellular Physiology·Federico Castro-MuñozledoErika Sánchez-Guzmán
Jun 12, 2013·Journal of Cell Science·Jessica L EisenbergJonathan C R Jones

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