Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

Nature
A W CraigN Sonenberg

Abstract

In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from recognition of the 5' cap structure (m7GpppX) of the mRNA by the cap-binding complex eIF4F. eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent RNA helicase, and eIF4G, which interacts with both eIF4A and eIF4E and enhances cap binding by eIF4E. The mRNA 3' polyadenylate tail and the associated poly(A)-binding protein (PABP) also regulate translational initiation, probably by interacting with the 5' end of the mRNA. In yeast and plants, PABP interacts with eIF4G but no such interaction has been reported in mammalian cells. Here, we describe a new human PABP-interacting protein, PAIP-I, whose sequence is similar to the central portion of eIF4G and which interacts with eIF4A. Overexpression of PAIP-1 in COS-7 cells stimulates translation, perhaps by providing a physical link between the mRNA termini.

References

Aug 1, 1978·European Journal of Biochemistry·F A AsselbergsH Bloemendal
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N SonenbergA J Shatkin
Jul 1, 1990·Molecular and Cellular Biology·D Munroe, A Jacobson
Mar 1, 1990·Molecular and Cellular Biology·F RozenN Sonenberg
Dec 1, 1995·Genes & Development·S Z Tarun, A B Sachs
Apr 1, 1994·Experimental Cell Research·M GörlachG Dreyfuss
Dec 1, 1995·Molecular and Cellular Biology·H YangT Lindsten
Jan 1, 1996·Acta neurochirurgica·T KamiryoL Steiner
Jan 24, 1997·Science·M W Hentze
Jun 1, 1997·Trends in Biochemical Sciences·A B Sachs, S Buratowski
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Z TarunA B Sachs
Aug 29, 1997·The Journal of Biological Chemistry·A Haghighat, N Sonenberg
Jan 7, 1998·Molecular and Cellular Biology·A GradiN Sonenberg

❮ Previous
Next ❯

Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·L L XuS Srivastava
Nov 16, 2005·Comptes rendus biologies·Federica PiccioniArturo C Verrotti
Apr 27, 1999·Trends in Biochemical Sciences·T V Pestova, C U Hellen
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·R Mendez, J D Richter
Jan 26, 2010·Nature Structural & Molecular Biology·Martin JinekJennifer A Doudna
Jun 20, 2008·Molecular BioSystems·Pamela Nicholson, Berndt Müller
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Barbara GorgoniNicola K Gray
Aug 22, 2009·Journal of Toxicology and Environmental Health. Part a·Michael J StobartJ David Knox
Apr 17, 2009·Molecular Biology of the Cell·Sophie MokasRachid Mazroui
Apr 16, 1999·The EMBO Journal·C H de Moor, J D Richter
May 9, 2001·Nucleic Acids Research·C FéralA Pawlak
Jun 24, 2010·Nucleic Acids Research·Jennifer M Bonderoff, Richard E Lloyd
Nov 20, 2012·Nucleic Acids Research·Emiliano P RicciThéophile Ohlmann
May 31, 2013·Journal of the Royal Society, Interface·Michael Margaliot, Tamir Tuller
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·A KahvejianN Sonenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.