Interaction of propranolol with S100 proteins of the cardiac muscle

European Journal of Pharmacology
K NakataniT Tanaka

Abstract

The cardioprotective activity of propranolol is believed to be independent of its beta-adrenoceptor antagonistic effect. Propranolol exerts this effect through a direct effect on the cardiac muscle, but the precise mechanism remains unclear. In this work, we demonstrated that propranolol binds to S100ao and S100L proteins with ED50 of approximately 1.0 microM without cation dependency and that this binding changes the conformation of these S100 proteins. Propranolol, however, was found to bind to and to change the conformation of S100C protein in the presence of Mg2+ or Zn2+ with ED50 of approximately 1.0 microM. No change was observed in the presence of Ca2+. Moreover, in the presence of Mg2+, the ED50 of L- and D- propranolol were approximately 0.8 and 2.0 microM, respectively. This study demonstrated for the first time, that the S100 proteins of the cardiac muscle are intracellular targets of propranolol, and that Mg2+ is a modulator of the cardioprotective activity of S100C protein.

References

Feb 18, 1992·European Journal of Pharmacology·M BoucherP Duchêne-Marullaz
Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·J Y Su, D A Malencik
Jun 25, 1966·Nature·R Howe, R G Shanks
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M VolpiM B Feinstein
Mar 1, 1994·Journal of the American College of Cardiology·R N DoughtyN Sharpe
Jan 1, 1993·Cardiology·D T Kelly
Jan 5, 1996·Biochemical and Biophysical Research Communications·A MargulisA Sitaramayya
Apr 18, 1996·Nature·J HeierhorstB E Kemp

❮ Previous
Next ❯

Citations

Dec 31, 1998·Journal of Cutaneous Pathology·N S McNutt
Mar 23, 2002·Molecular and Cellular Biology·Xiao-Jun DuJörg Heierhorst
May 21, 2008·Journal of Pharmacological Sciences·Toshio TanakaYuhei Nishimura
Nov 9, 2019·NPJ Precision Oncology·Maiko SasakiJack L Arbiser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.