PMID: 3016049Aug 1, 1986

Interaction of salivary fibronectin with oral streptococci

Journal of Dental Research
J P Babu, M K Dabbous

Abstract

Immunoreactive Fibronectin (Fn) has been demonstrated in stimulated human parotid saliva by western blot analysis and also found to be a component of the artificial tooth pellicles derived from hydroxyapatite (HA) beads coated with parotid saliva. Saliva depleted of gelatin-binding components showed a significantly lower degree of reactivity with anti-Fn antibodies than did the control saliva when tested by and enzyme-linked immunosorbent assay (ELISA). Depletion of gelatin-binding components from saliva was also found to affect the degree of saliva-mediated aggregation of four of the seven oral streptococci tested [Streptococcus mutans strains GS-5 and OMZ 176, S. sobrinus, and S. rattus]. Similarly, the adherence of the same four micro-organisms to the artificial tooth pellicles (derived form saliva which had previously been depleted of gelatin-binding component) was significantly inhibited (37-53%) when compared with the control saliva-coated HA beads. Pre-treatment of streptococci with 100 micrograms of soluble Fn also caused a 34-57% inhibition of adherence of the same oral streptococci to saliva-treated HA beads. Quantitation of Fn in human parotid saliva showed that the amounts of immunoreactive Fn varied form 2 to 6 mic...Continue Reading

References

Jan 1, 1979·Journal of Dental Research·B R ZetterJ S Greenspan
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 14, 1978·Nature·P Kuusela
Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·E Engvall, E Ruoslahti
Feb 1, 1975·The Journal of Experimental Medicine·E Ruoslahti, A Vaheri
Aug 1, 1982·Infection and Immunity·F Espersen, I Clemmensen
Apr 1, 1983·Infection and Immunity·E B Myhre, P Kuusela
Feb 1, 1984·Journal of Bacteriology·P SpezialeT Wadström
Jan 1, 1983·Infection and Immunity·W A Simpson, E H Beachey
Feb 1, 1984·Canadian Journal of Microbiology·K G SkerlW M Scheld
Jun 1, 1981·The Journal of Infectious Diseases·D E WoodsJ A Bass
Sep 1, 1981·Infection and Immunity·J E Doran, R H Raynor
Sep 1, 1961·The Journal of the American Dental Association·H H CHAUNCEY

Citations

Dec 1, 1994·International Journal of Food Microbiology·D W HartyK W Knox
Aug 17, 2000·International Dental Journal·M C Llena-PuyL Forner-Navarro
Dec 1, 1990·American Journal of Respiratory Cell and Molecular Biology·C M MasonA R Dal Nogare
Sep 14, 2010·European Journal of Oral Sciences·Lars Eliasson, A Carlén
Oct 17, 2009·Oral Microbiology and Immunology·A NistorY Myal
Feb 1, 1994·Archives of Oral Biology·L M Switalski, W G Butcher
May 1, 1988·Journal of Clinical Periodontology·G Tynelius-Bratthall
Aug 1, 1989·The Journal of the American Dental Association·I D Mandel
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Howard F Jenkinson, R J Lamont
Aug 2, 2003·International Journal of Systematic and Evolutionary Microbiology·Huichun TongXiuzhu Dong
Jan 1, 1994·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F A Scannapieco

Related Concepts

95 kDa gelatin-binding protein, human
Adhesiveness
Carrier Proteins
Plasma Membrane
SDS-PAGE
Enzyme-Linked Immunosorbent Assay
Fibronectins
Hydroxyapatites
Plasma Protein Binding Capacity
Salivary Peptides

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.