PMID: 1201766Nov 21, 1975Paper

Interaction of secretin and insulin on human forearm metabolism

European Journal of Clinical Investigation
D J ChisholmT Pozefsky

Abstract

The effect of secretin on forearm metabolism (muscle compartment) was examined in the presence of low and high concentrations of insulin. Continuous infusions (30 min. duration) of secretin 12 ng/min. (SEC), insulin 160 ng/min. (INS) or these doses of insulin and secretin together (INS + SEC) were delivered into the brachial arteries of normal volunteers. SEC alone was without significant effect on forearm metabolism. INS as previously reported, stimulated glucose and potassium uptake and inhibited the output of some amino acids from the deep venous bed. The two hormones together (INS + SEC) increased maximum lactate (p less than 0.025) and alanine output (p less than 0.005) beyond that observed with INS alone. A marked calcium output occurred (p less than 0.001) with the combined infusion which was not observed with either hormone alone. Potassium metabolism with INS + SEC was similar to that observed with INS alone. These results suggest that these two hormones, acting in concert, stimulate glycolysis and net calcium efflux. This joint action of insulin and secretin may have a physiological role in the immediate postprandial period.

References

Jul 2, 1966·Lancet·R H UngerJ Dupré
Apr 1, 1967·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Jan 1, 1974·British Medical Bulletin·S R Bloom
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M BodanszkyS I Said
Jul 1, 1972·The Journal of Clinical Investigation·F SanteusanioR H Unger
May 1, 1971·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D J ChisholmL Lazarus
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Mar 1, 1970·The Journal of Clinical Investigation·E W KraegenL Lazarus
Aug 1, 1969·The Journal of Clinical Investigation·D J ChisholmL Lazarus
Aug 1, 1956·Biochimica Et Biophysica Acta·F H BRUNS, H D HORN
May 1, 1957·The Journal of Clinical Investigation·R ANDRESK L ZIERLER
Jan 1, 1962·The Journal of Clinical Investigation·R ANDRESK L ZIERLER

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Citations

Dec 1, 1993·Steroids·W P MeehanM F Saad
Nov 1, 1987·Baillière's Clinical Endocrinology and Metabolism·P C Butler, P D Home
Jul 1, 1979·Clinics in Endocrinology and Metabolism·J R Hayes, R W Henry
Jul 1, 1982·Clinics in Endocrinology and Metabolism·J DupreN W Rodger
May 20, 1998·Clinical and Experimental Pharmacology & Physiology·S J ClelandJ M Connell

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