Interaction of St John's wort with conventional drugs: systematic review of clinical trials

BMJ : British Medical Journal
Edward MillsGordon Guyatt

Abstract

To determine the methodological quality of clinical trials that examined possible interactions of St John's wort with conventional drugs, and to examine the results of these trials. Systematic review. Electronic databases from inception to April 2004, reference lists from published reports, and experts in the field. Eligible studies were prospective clinical trials evaluating the pharmacokinetic effect of St John's wort on the metabolism of conventional drugs. Two reviewers selected studies for inclusion and independently extracted data. 22 pharmacokinetic trials studied an average of 12 (SD 5) participants; 17 trials studied healthy volunteers and five studied patients. Most (17) studies used a "before and after" design; four studies used control groups other than the active group. Three studies randomised the sequence of administration or the participants to study arms or periods; three studies blinded participants or investigators. In 15 trials, investigators independently assayed the herb. Of 19 trials with available plasma data, three found no important interaction (change in area under the curve < 20%) and 17 found a decrease in systemic bioavailability of the conventional drug; in seven studies the 95% confidence interva...Continue Reading

References

Feb 22, 2000·Lancet·S C PiscitelliJ Falloon
Nov 10, 2000·International Journal of Clinical Pharmacology and Therapeutics·I MaiI Roots
Feb 17, 2001·Clinical Pharmacology and Therapeutics·D DürrK Fattinger
Feb 17, 2001·Clinical Pharmacology and Therapeutics·A H BursteinW Theodore
Mar 27, 2001·Complementary Therapies in Medicine·K J ThomasP Coleman
Oct 11, 2001·Journal of Clinical Psychopharmacology·C A RobyA H Burstein
Jun 28, 2002·Clinical Pharmacology and Therapeutics·Zaiqi WangStephen D Hall
Aug 22, 2002·Journal of the National Cancer Institute·Ron H J MathijssenAlex Sparreboom
Oct 24, 2002·British Journal of Clinical Pharmacology·L HendersonP Arlett
Jan 25, 2003·Clinical Pharmacology and Therapeutics·George K DresserRichard B Kim
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ingrid MaiIvar Roots
Jul 2, 2003·Psychosomatics·Paul HammernessUNKNOWN Natural Standard Research Collaboration
Sep 18, 2003·JAMA : the Journal of the American Medical Association·John S MarkowitzKenneth D Chavin
Nov 18, 2003·British Journal of Clinical Pharmacology·Arabelle PfrunderJuergen Drewe
Dec 10, 2003·Clinical Pharmacology and Therapeutics·Stephen D HallJ Christopher Gorski
Dec 19, 2003·Journal of Clinical Pharmacology·Mary F HebertAnne M Larson
Dec 19, 2003·Journal of Clinical Pharmacology·Takuya MorimotoShigeyuki Nakano
Mar 6, 2004·Clinical Pharmacology and Therapeutics·Lian-Sheng WangHong-Hao Zhou
Apr 20, 2004·British Journal of Clinical Pharmacology·Xuemin JiangAndrew J McLachlan

❮ Previous
Next ❯

Citations

May 11, 2011·Inflammatory Bowel Diseases·Jimmy K Limdi, Rhys Owain Butcher
Feb 16, 2006·European Journal of Clinical Pharmacology·Rajanikanth MadabushiVeronika Butterweck
Aug 21, 2007·Wiener medizinische Wochenschrift·Karin Kraft
Dec 21, 2010·Wiener medizinische Wochenschrift·Matthias Unger
Dec 6, 2011·Archives of Pharmacal Research·Dong Hee NaHye Suk Lee
May 16, 2008·Clinical Pharmacokinetics·Veronika Butterweck, Hartmut Derendorf
Apr 12, 2013·Primary Health Care Research & Development·Rachel PerryEdzard Ernst
Mar 5, 2014·Journal of Agricultural and Food Chemistry·Kevin D WelchDaniel Cook
Sep 22, 2005·Therapeutic Drug Monitoring·Edward MillsGordon Guyatt
Feb 7, 2012·Complementary Therapies in Medicine·Karen Pilkington, Anelia Boshnakova
Sep 14, 2010·Explore : the Journal of Science and Healing·Chung-Wah ChengZhao-Xiang Bian
May 25, 2005·Paediatric Anaesthesia·Jerrold Lerman
Jan 7, 2005·Molecular Nutrition & Food Research·Ivonne M C M RietjensGerrit M Alink
Mar 16, 2006·Journal of Clinical Laboratory Analysis·Amitava DasguptaKathy Szelei-Stevens
Jan 21, 2006·Alimentary Pharmacology & Therapeutics·L Langmead, D S Rampton
Oct 3, 2006·British Journal of Clinical Pharmacology·D L WhittenH Wohlmuth
Jun 3, 2008·British Journal of Pharmacology·M I Mohammed AbdulA J McLachlan
Feb 26, 2008·British Journal of Clinical Pharmacology·Hiromitsu ImaiKyoichi Ohashi
Nov 16, 2006·Complementary Therapies in Medicine·Karen PilkingtonJanet Richardson
Aug 17, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Siegfried KasperEugenio Aguglia
Apr 20, 2016·Therapeutic Advances in Endocrinology and Metabolism·Marcus May, Christoph Schindler
Feb 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zongxi SunShouying Du
Feb 8, 2018·The Journal of Pharmacy and Pharmacology·Sigrun Chrubasik-HausmannAndrew J McLachlan
Aug 16, 2006·Phytotherapy Research : PTR·Vikas Kumar
Aug 2, 2006·The Oncologist·Irma MeijermanJan H M Schellens
Jun 19, 2013·Drug Metabolism and Drug Interactions·Sadık Kadri Açıkgöz, Eser Açıkgöz
Sep 30, 2017·Journal of Patient Experience·Mohamed RashrashLawrence M Brown
May 16, 2017·BioMed Research International·Gihyun Lee, Hyunsu Bae
Aug 5, 2017·Diabetology & Metabolic Syndrome·Ramesh C GuptaBasil D Roufogalis
Jun 4, 2020·Nutrients·Rafat A Siddiqui, Mohammed H Moghadasian
Jun 13, 2015·Cancer Prevention Research·Soumen K MannaFrank J Gonzalez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Pharmacology
Rajanikanth MadabushiVeronika Butterweck
© 2022 Meta ULC. All rights reserved