Interaction of staphylococcal alpha toxin and the estrogenic hormone diethylstilbestrol.

Applied Microbiology
W Yotis, Z Savov

Abstract

Previous work in this laboratory showed that diethylstilbestrol was capable of suppressing induced furunculosis in rabbits. The present study indicates that the synthetic estrogenic hormone diethylstilbestrol which is used for acne, estrogen deficiency, cancer, and other disorders, can reduce the cytolytic action of staphylococcal alpha toxin. The cytotoxic action of purified alpha toxin for tissue cultures was evaluated by use of such parameters as total and viable cell counts, glucose, and protein determination, and cytopathic effects (CPE) in the presence and absence of steroids. To 3-day-old primary rabbit baby kidney tissue cultures, 1 to 5 mug of diethylstilbestrol per ml was added; growth of tissue cultures in Eagles medium was continued till the 6th day, and then one tissue cytopathic dose per milliliter of alpha toxin was added, and the subsequent fate of tissue cultures was assayed. Such cultures yielded higher total and viable cell counts, utilized more glucose, and contained more protein than the control cultures. In control cultures, CPE was observed on the 3rd hr after the addition of alpha toxin, and it was complete in 24 hr, whereas in tissue cultures treated with diethylstilbestrol, the CPE was significantly re...Continue Reading

References

Oct 1, 1968·Applied Microbiology·W Yotis, T Fitzgerald
Jan 1, 1967·Acta Pathologica Et Microbiologica Scandinavica·H O Hallanger, S Bengtsson
Nov 1, 1967·Journal of Bacteriology·W W Yotis
Jul 23, 1965·Annals of the New York Academy of Sciences·A W Bernheimer
Mar 1, 1969·Canadian Journal of Microbiology·W W Yotis, J M Cummings
Feb 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·J S YOUNGNER
Jan 1, 1956·The Journal of Experimental Medicine·J M SMITH, R J DUBOS
Feb 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·V I OYAMA, H EAGLE
Jul 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·J J ELIAS
Jan 1, 1961·The Journal of Experimental Medicine·A P THAL, W EGNER
Aug 1, 1961·Biological Reviews of the Cambridge Philosophical Society·E N WILLMER
Feb 1, 1963·Endocrinology·S A KAPLAN, C S SHIMIZU
Mar 1, 1963·Journal of General Microbiology·A W BERNHEIMER, L L SCHWARTZ
Aug 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·H UI, G C MUELLER

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