PMID: 8603047Jan 1, 1996Paper

Interaction of steroid hormone receptors with transcription factors involves chromatin remodelling

The Journal of Steroid Biochemistry and Molecular Biology
M BeatoM Truss

Abstract

The mechanism by which steroid hormones modulate promoter utilization is not clear. Evidence from transfection studies and cell-free assays points to an interaction of the hormone receptors with general transcription factors, as well as with sequence-specific transcription factors. Moreover co-activators or transcription intermediary factors, have been identified which could mediate some of the transcriptional effects of the hormone-receptor complex. However, in addition to this interaction of receptors with proteins directly involved in transcription, a participation of chromatin structure in gene regulation by steroid hormones is becoming increasingly evident. In the case of the MMTV promoter, the nucleosomal organization seems to be responsible for transcriptional repression prior to hormonal stimulation. This effect is due to occlusion by a nucleosome positioned on the MMTV promoter sequences in such a way that essential transcription factors cannot access their recognition sites. Following hormone induction, a remodelling of the nucleosome structure takes place which enables a whole complement of sequence specific transcription factors to assemble on the promoter. Since a complete occupancy of binding sites does not take p...Continue Reading

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Citations

Jul 21, 1998·Molecular Reproduction and Development·J J LareyreM C Orgebin-Crist
Apr 28, 2001·Molecular and Cellular Endocrinology·A L CabralV R Martins
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·E CastañoA C Notides
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Feb 24, 2007·Molecular and Cellular Endocrinology·Allison H MaffeyJuan Ausió
Sep 1, 2005·Journal of Biomolecular Screening·Roy M KatsoRaymond V Merrihew
Jan 18, 2006·Molecular and Cellular Endocrinology·Jamshed R Tata
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Jul 1, 1997·Analytical Biochemistry·A JoyeuxJ C Nicolas
Oct 26, 2000·Neuropeptides·J P QuinnC M Payne

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