Interaction of steroids with the transport system of glucose in human erythrocytes

Journal of Cellular Physiology
L LackoP Geck

Abstract

Steroids inhibit the exchange transport of glucose in human erythrocytes. The extent of inhibition is roughly correlated to the affinity of the steroids to the membrane lipids. All C-21-steroids tested show a competitive inhibition while the C-19-steriods show different types of inhibition. 5Beta-androstane-3,17-dione acts as a competitive inhibitor. The inhibition by testosterone is of mixed type, while with androst-4-ene-3,17-dione and 5alpha-androstane-3,17-dione a non-competitive inhibition is observed. In this case two inhibitor molecules can be bound per transport molecule. The "non-competitive" inhibitors compete also to some extent with the glucose binding. This effect, however, is at high inhibitor concentrations masked by the more powerful non-competitive inhibition. Competitive and non-competitive inhibitors compete with each other. The structural requirements for the different types of inhibition are discussed.

References

Jun 1, 1974·Archives of Biochemistry and Biophysics·S J Masiak, P G LeFevre
Oct 1, 1973·Journal of Cellular Physiology·L LackoP Geck
Apr 1, 1974·Journal of Cellular Physiology·L LackoP Geck
Feb 1, 1972·European Journal of Biochemistry·L LackoH Kromphardt
Aug 1, 1972·Journal of Cellular Physiology·L LackoP Geck
Apr 1, 1965·Biochemical Pharmacology·G WEISSMANN, H KEISER

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Citations

Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·G J Strugala, W Forth
Jan 1, 1980·Journal of Steroid Biochemistry·F PicardD Duval
Jan 1, 1980·Journal of Steroid Biochemistry·F HomoD Duval
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Aug 1, 1978·Journal of Cellular Physiology·L LackoI Lacko
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Rita R Kalyani, Adrian S Dobs
Apr 24, 2009·American Journal of Physiology. Cell Physiology·Alejandra PérezAlejandro M Reyes
Jun 1, 2020·Pflügers Archiv : European journal of physiology·Hélène Guizouarn, Benoit Allegrini
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Nov 1, 1985·Japanese Journal of Pharmacology·H Kaya, T Saito
Jun 19, 2002·Biochemistry·Alejandro M ReyesJuan Carlos Vera

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