Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease

The European Journal of Neuroscience
Sungwoo AhnLeonid L Rubchinsky

Abstract

Parkinson's disease pathophysiology is marked by increased oscillatory and synchronous activity in the beta frequency band in cortical and basal ganglia circuits. This study explores the functional connections between synchronized dynamics of cortical areas and synchronized dynamics of subcortical areas in Parkinson's disease. We simultaneously recorded neuronal units (spikes) and local field potentials (LFP) from subthalamic nucleus (STN) and electroencephalograms (EEGs) from the scalp in parkinsonian patients, and analysed the correlation between the time courses of the spike-LFP synchronization and inter-electrode EEG synchronization. We found the (non-invasively obtained) time course of the synchrony strength between EEG electrodes and the (invasively obtained) time course of the synchrony between spiking units and LFP in STN to be weakly, but significantly, correlated with each other. This correlation is largest for the bilateral motor EEG synchronization, followed by bilateral frontal EEG synchronization. Our observations suggest that there may be multiple functional modes by which the cortical and basal ganglia circuits interact with each other in Parkinson's disease: not only may synchronization be observed between some...Continue Reading

References

Jan 5, 2000·Human Brain Mapping·J P LachauxF J Varela
Dec 12, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·E Neumann, A Pikovsky
Mar 11, 2004·Journal of Neurophysiology·Jose M HurtadoKaren A Sigvardt
Jun 11, 2004·IEEE Transactions on Bio-medical Engineering·Gerwin SchalkJonathan R Wolpaw
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua A GoldbergHagai Bergman
Apr 2, 2005·Nature Reviews. Neuroscience·Alfons Schnitzler, Joachim Gross
Jan 16, 2007·NeuroImage·Hong YuDavid E Vaillancourt
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletPeter J Magill
Feb 24, 2009·Experimental Neurology·Alexandre Eusebio, Peter Brown
Dec 1, 2009·Experimental Neurology·Camille de SolagesHelen Bronte-Stewart
Feb 26, 2010·Journal of Neurophysiology·Choongseok ParkLeonid L Rubchinsky
Apr 20, 2010·Experimental Neurology·Carlo TessaMario Mascalchi
Dec 15, 2010·Brain : a Journal of Neurology·Vladimir LitvakPeter Brown
Jun 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·M M McCarthyN Kopell
Aug 20, 2011·PLoS Computational Biology·Rosalyn J MoranPeter Brown
May 15, 2012·Nonlinear Dynamics·Leonid L RubchinskyRobert M Worth
Aug 28, 2012·Experimental Neurology·Edward Stein, Izhar Bar-Gad
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Coralie de HemptinnePhilip A Starr
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shoichi A ShimamotoPhilip A Starr
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ashwini OswalPeter Brown
Jun 4, 2014·The European Journal of Neuroscience·John-Stuart BrittainPeter Brown

❮ Previous
Next ❯

Citations

May 26, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Meili LuKenneth A Loparo
Sep 1, 2020·Journal of Sleep Research·Gustavo Zampier Dos Santos LimaMarcelo M S Lima
May 17, 2017·Physical Review. E·Giovanni Russo
Jan 10, 2017·Frontiers in Computational Neuroscience·Sungwoo AhnLeonid L Rubchinsky
Apr 9, 2019·Cognitive Neurodynamics·Bing HuLiqing Zong
Nov 3, 2020·Frontiers in Neuroscience·Brian Y HwangKelly A Mills

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.