PMID: 6413999Jan 1, 1983Paper

Interaction of synthetic opioid metenkephalin peptide analogs, Lilly 127623 and FK 33-824 with indole hallucinogens: antagonism of N,N-dimethyltryptamine- and LSD-induced disruption of food-rewarded bar pressing behavior in the rat

Psychopharmacology
D Ruffing, E F Domino

Abstract

The selected opioid metenkephalin synthetic peptide analogs Lilly (LY) 127623 and FK 33-824 were tested for behavioral dose effects and potential interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement fixed-ratio 4 (FR-4) behavioral bar pressing schedule, i.e., a reward of 0.01 ml sugar-sweetened evaporated milk was earned on every fourth bar press. DMT (3.2 mg/kg) and LSD (0.1 mg/kg), administered IP following a 0.9% NaCl 15-20-min control pretreatment, disrupted established food-rewarded FR-4 bar pressing in a consistent and reproducible manner. Animals pretreated IP with predetermined behaviorally noneffective doses of LY 127623 (0.01-0.32 mg/kg) and FK 33-824 (0.001-0.01 mg/kg) 15-20 min prior to receiving DMT demonstrated significant antagonism to DMT-induced disruption of FR-4 bar pressing, while doses of 0.10-0.32 mg/kg LY 127623 and 0.00032-0.0032 mg/kg FK 33-824 significantly antagonized LSD-induced behavioral effects.

References

Jan 1, 1981·Peptides·G A OlsonD H Coy
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Szara
Jan 1, 1980·Endeavour·D de Wied
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·J S Morley
Jan 1, 1980·Progress in Medicinal Chemistry·C R BeddellS Wilkinson
May 1, 1980·British Journal of Pharmacology·P JennerC M Thanki
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R A Glennon, J A Rosecrans
Aug 1, 1981·Journal of Pharmaceutical Sciences·D E Nichols
Nov 27, 1981·Science·J L Marx
Jan 1, 1981·Advances in Experimental Medicine and Biology·B L Jacobs, M E Trulson
Mar 1, 1980·Journal of Medicinal Chemistry·R A GlennonG M Anderson
Aug 29, 1980·European Journal of Pharmacology·E B NielsenC Braestrup

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Citations

Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·E F Domino
Sep 1, 1984·Pharmacology, Biochemistry, and Behavior·D J MoklerR H Rech
Nov 25, 2011·Advances in Medical Sciences·D OwczarekB Kuśnierz-Cabała
Jul 24, 2018·ACS Chemical Neuroscience·Lindsay P Cameron, David E Olson

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