PMID: 9420710May 1, 1994Paper

Interaction of technetium 99m-labeled teboroxime with red blood cells reduces the compound's extraction and increases apparent cardiac washout

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
S T DahlbergJ A Leppo

Abstract

99mTc-labeled teboroxime shows high myocardial extraction in both in vivo animal and in vitro cell culture and isolated heart studies. Whereas in vivo studies show rapid myocardial clearance of teboroxime, in vitro cell culture and isolated heart studies show slower washout comparable to that of 201Tl. Binding of teboroxime to blood components may contribute to these conflicting results. We measured teboroxime extraction in the isolated blood-perfused rabbit heart after injection in saline solution, brief incubation in red blood cell perfusate, or 4-hour incubation with human red blood cells. Teboroxime in saline solution showed high extraction (Emax = 0.89 +/- 0.02; Enet = 0.69 +/- 0.02), whereas brief incubation in perfusate (Emax = 0.60 +/- 0.06; Enet = 0.48 +/- 0.05) or prolonged incubation with human red blood cells (Emax = 0.43 +/- 0.09; Enet = 0.38 +/- 0.07) resulted in reduced extraction. Teboroxime clearance was similar for all groups and was slower than 201Tl clearance. Analysis of total residual cardiac teboroxime (comparable to external imaging) showed that teboroxime clearance was biexponential. Reduced extraction of teboroxime in red blood cells resulted in an increased size of the rapidly clearing (unextracted) f...Continue Reading

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Citations

May 2, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Seth T Dahlberg
Aug 1, 1996·Journal of the American College of Cardiology·R S BeanlandsT D Ruddy
Feb 10, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·N TakahashiJ A Leppo
May 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G JohnsonR D Okada
Dec 23, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·T A HollyS T Dahlberg
Feb 8, 2019·Current Radiopharmaceuticals·Wei Fang, Shuang Liu

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