PMID: 6986954Feb 17, 1980Paper

Interaction of the anti-estrogen CI-628 and estradiol on plasma LH and hypothalamic LH-RH in the female rat

Brain Research
F GoganC Kordon

Abstract

The effects of the anti-estrogen Ci-628 have been tested on both plasma LH and hypothalamic LH-RH content in ovariectomized or ovariectomized, estradiol (E2)-implanted rats, in order to correlate those parameters with the [3H]E2 retention in the hypothalamus and the pituitary. Incresing doses of CI-628 induced a dose-dependent inhibition of [3H]E2 retention in both cytosolic and nuclear fractions of the pituitary. In contrast, hypothalamic retention of [3H]E2 is only inhibited significantly with higher doses of CI-628 (2.4 and 24 mg/kg). In ovariectomized rats, only a high dose of CI-628 (24 mg/kg) is able to decrease elevated LH levels observed following castration. In the presence of E2, CI-628 has both estrogenic and anti-estrogenic properties on LH secretion. CI-628 acts at the pituitary level to decrease the tissue sensitivity to LH-RH, but has no effect on mediobasal hypothalamic (MBH) LH-RH content.

References

Sep 1, 1975·Molecular and Cellular Endocrinology·F Capony, H Rochefort
Oct 1, 1978·Archives of Internal Medicine·W Locke
Nov 1, 1978·Acta Endocrinologica·L J BaudendistelT S Ruh
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·W E Stumpf
Oct 4, 1974·Nature·J H ClarkJ N Anderson
Oct 1, 1970·The American Journal of Anatomy·W E Stumpf
May 1, 1974·Endocrinology·J A Vilchez-MartinezA V Schally
Sep 15, 1973·The Journal of Comparative Neurology·D Pfaff, M Keiner
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderL E Reichert
Jul 1, 1966·Endocrinology·M R CallantineO P O'Brien

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