Interaction of the growth hormone releasing peptide hexarelin with somatostatin

Clinical Endocrinology
A F MassoudC G Brook

Abstract

Growth hormone releasing peptides (GHRPs) are potent growth hormone (GH) secretagogues. Their interaction with growth hormone releasing hormone (GHRH) has been studied extensively. Data on their interaction with somatostatin (SS) are limited. The aim of this study was to determine the effect of changing SS tone and the effects of SS withdrawal on the somatotroph response to hexarelin and GHRH, alone or in combination. In addition, we studied the effect of SS on the prolactin (PRL) and cortisol response to hexarelin. Boluses of saline, hexarelin (1 microgram/kg), GHRH-(1-29)-NH2 (1 microgram/kg) or hexarelin plus GHRH-(1-29)-NH2 were administered intravenously 1 hour after the start of a 3-hour constant intravenous infusion of saline, SS(1-14) (20 micrograms/m2/h) (SS20) or SS(1-14) (50 micrograms/m2/h) (SS50). In a second group of studies, the same boluses as above were administered intravenously at the time of withdrawal of a 3-hour constant intravenous infusion of saline or SS20. In a subset of the second group of studies, saline, hexarelin (0.5 microgram/kg) or GHRH-(1-29)-NH2 (0.5 microgram/kg) was administered intravenously two hours before the withdrawal of the SS(1-14) infusion, which was administered at a higher dose of...Continue Reading

Citations

Mar 20, 1999·Baillière's Clinical Endocrinology and Metabolism·E GhigoF Camanni
Jun 20, 2002·Clinical Endocrinology·Gianluca AimarettiEmanuela Arvat
Sep 1, 1999·Clinical Endocrinology·S Chappel
Dec 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leon S FarhyJohannes D Veldhuis

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