PMID: 8970957Dec 1, 1996Paper

Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat

Journal of Virology
F TieC Giam

Abstract

Human T-lymphotropic virus type 1 Tax interacts specifically with the cellular transcription factor CREB and the viral 21-bp repeat element to form a Tax-CREB-DNA ternary complex which mediates activation of viral mRNA transcription. Analyses of Tax and Tax mutants indicate that, like CREB, Tax incorporates into the ternary complex as a dimer. The ability of Tax to form a dimer is necessary for its interaction with CREB and the 21-bp element. Analyses of several Tax mutants with amino acid substitutions spanning residues 123 to 204 indicate that intersubunit Tax dimerization correlates with its ability to assemble into the ternary complex and activate transcription. Tax also enhances the DNA binding activities of specific bZip domains in vitro. The ability of Tax to enhance DNA binding of bZip proteins can be explained in part by Tax dimerization. This activity alone is not sufficient for transactivation. A dual amino acid substitution mutant of Tax, M47 (L319R, L320S), completely abrogated for activation of the human T-lymphotropic virus type 1 long terminal repeat as a result of a defect in the transactivation domain, continues to stimulate binding of bZip proteins to DNA.

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Citations

Jun 25, 1999·AIDS Research and Human Retroviruses·M MoriuchiA S Fauci
Nov 21, 2007·International Reviews of Immunology·Benoit Barbeau, Jean-Michel Mesnard
Nov 24, 1999·The Journal of Biological Chemistry·A L Kimzey, W S Dynan
Aug 8, 2001·International Journal of Experimental Pathology·J M JohnsonG Franchini
Jun 15, 2007·The FEBS Journal·Yeung-Tung Siu, Dong-Yan Jin
Sep 13, 2005·Oncogene·Shao-Cong Sun, Shoji Yamaoka
Feb 2, 2016·Viruses·Jessica L MartinLouis M Mansky

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