PMID: 8950614Jan 1, 1996Paper

Interaction of the signalling pathways of insulin-like growth factor-I and sex steroids in the neuroendocrine hypothalamus

Hormone Research
L M Garcia-SeguraI Torres-Alemán

Abstract

Among the numerous endocrine signals that affect the central nervous system, sex steroids play an important role. It has been recently postulated that part of the effects of these hormones on the brain may be mediated by trophic factors, such as insulin-like growth factor I (IGF-I). Both estradiol and IGF-I increase the survival and differentiation of developing fetal rat hypothalamic neurons in culture. The effect of estradiol is blocked by the pure estrogen receptor antagonist ICI 182,780, by an antisense oligonucleotide to the estrogen receptor, and by an antisense oligonucleotide to IGF-I. In turn, the effect of IGF-I is blocked by ICI 182,780 and by the antisense oligonucleotide to the estrogen receptor. These findings indicate that estrogen-induced activation of the estrogen receptor in developing hypothalamic neurons requires the presence of IGF-I and that both estradiol and IGF-I use the estrogen receptor to mediate their trophic effects on hypothalamic cells. In vivo, sex steroids affect IGF-I levels in the endocrine hypothalamus. IGF-I levels in tanycytes, a specific subtype of glial cells present in the arcuate nucleus and median eminence, are sexually dimorphic in the rat, increase with the onset of puberty, and are...Continue Reading

Citations

Sep 19, 2009·Acta Neuropathologica·Markus KippCordian Beyer
Feb 21, 2008·Neuromolecular Medicine·M Llorens-MartínJosé L Trejo
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Denis HabauzitChristian Saligaut
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·S J Lee, B S McEwen
Jul 23, 2008·Journal of Neurochemistry·José A Rodríguez-NavarroMaría A Mena
Feb 24, 2010·Brain Research·Fabian BaertlingMarkus Kipp
Jan 31, 2019·Journal of Neuroendocrinology·Esteban RodríguezJuan Luis Blázquez
Apr 17, 2004·Journal of Neurochemistry·Toshihiro TakaoKaren J Chandross
Feb 24, 2001·Annals of Medicine·A Trotter, F Pohlandt
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Apr 28, 2005·Experimental Biology and Medicine·Shabrine S Daftary, Andrea C Gore

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.