Interaction of the tachykinin NK3 receptor agonist senktide with behavioral effects of cocaine in marmosets (Callithrix penicillata)

Peptides
Maria A De Souza SilvaM Barros

Abstract

Brain neuropeptide transmitters of the tachykinin family are involved in the organization of many behaviors. However, little is known about their contribution to the behavioral effects of drugs of abuse. Recently, antagonism of the tachykinin NK3-receptor (NK3-R), one of the three tachykinin receptors in the brain, was shown to attenuate the acute and chronic behavioral effects of cocaine in rats and the acute effects in non-human primates. In order to expand these findings we investigated the effects of the NK3-R agonist, succinyl-[Asp6, Me-Phe8]SP(6-11) (senktide), on the acute behavioral effects of cocaine in marmoset monkeys (Callithrix penicillata) using a figure-eight maze procedure. Animals were pretreated with senktide (0, 0.1, 0.2, 0.4 mg/kg, s.c.), and received either a treatment with cocaine (10 mg/kg) or saline (i.p.). Cocaine increased locomotor activity and the duration of aerial scanning behavior, but reduced exploratory activity, bodycare activity, the frequency of aerial scanning, and terrestrial glance behavior. Senktide blocked the effects of cocaine on locomotor activity, but enhanced the cocaine effects on exploratory activity, aerial scanning frequency, and terrestrial glance behavior. Senktide alone did n...Continue Reading

References

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Mar 10, 2000·European Journal of Pharmacology·M E AlburgesG R Hanson
Feb 13, 2001·Journal of Internal Medicine·T HökfeltJ Wahren
Feb 22, 2002·Neuroscience and Biobehavioral Reviews·Marilia Barros, Carlos Tomaz
May 31, 2002·Pharmacological Reviews·Cinzia SeveriniVittorio Erspamer
Dec 9, 2003·European Journal of Pharmacology·Marilia BarrosCarlos Tomaz
Aug 30, 2005·Neuroscience Letters·Franca M PlacenzaSuzanne Erb
Apr 11, 2006·European Journal of Pharmacology·Maria A De Souza SilvaMarilia Barros

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Citations

Jun 15, 2007·Psychopharmacology·Judith A SiuciakS McLean
Feb 24, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S SchäbleM A de Souza Silva
Jun 9, 2009·Neuropharmacology·Chinwe A Nwaneshiudu, Ellen M Unterwald
May 24, 2008·Physiology & Behavior·Marcos A López PatiñoIrina V Zhdanova
Mar 7, 2008·Journal of Neuroscience Methods·Bo ZhangYuan-Ye Ma
Sep 25, 2007·Physiology & Behavior·Marcos A López-PatiñoIrina V Zhdanova
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Tatiana ForoudHoward J Edenberg
Oct 16, 2012·Drug and Alcohol Dependence·Jonathan L MelamedMarilia Barros
Aug 30, 2008·Reviews in the Neurosciences·Maria A de Souza SilvaChristian P Müller
Sep 15, 2020·ACS Chemical Neuroscience·Wen-Wen ZhangYu-Xia Chu

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