Interaction of the two frontal eye fields before saccade onset

Journal of Neurophysiology
J SchlagM Schlag-Rey

Abstract

A normal environment often contains many objects of interest that compete to attract our gaze. Nevertheless, instead of initiating a flurry of conflicting signals, central populations of oculomotor neurons always seem to agree on the destination of the next saccade. How is such a consensus achieved? In a unit recording and microstimulation study on trained monkeys, we sought to elucidate the mechanism through which saccade-related cells in the frontal eye fields (FEF) avoid issuing competing commands. Presaccadic neuronal activity was recorded in one FEF while stimulating the contralateral FEF with low-intensity currents that evoked saccades. When an eye-movement cell was isolated, we determined: the movement field of the cell, the cell's response to contralateral FEF microstimulation, the cell's response when the evoked saccade was in the preferred direction of the cell (using the collision technique to deviate appropriately the evoked saccade vector), and the cell's response to a stimulation applied during a saccade in the cell's preferred direction, to reveal a possible inhibitory effect. Complete results were obtained for 71 stimulation-recording pairs of FEF sites. The unit responses observed were distributed as follows: 3...Continue Reading

References

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Citations

Jan 28, 2004·Annual Review of Psychology·Jeffrey D Schall
Mar 24, 2006·The European Journal of Neuroscience·Thomas NyffelerChristian W Hess
Oct 25, 2013·Journal of Neurophysiology·Tyler R PeelBrian D Corneil
May 24, 2019·PeerJ·Costanza PeinkhoferDaniel Kondziella
Oct 17, 1998·Journal of Neurophysiology·N AmadorJ Schlag
Sep 5, 2002·Muscle & Nerve·Veit Stuphorn, Jeffrey D Schall
Sep 19, 2003·Journal of Neurophysiology·Tirin Moore, Mazyar Fallah
May 22, 2008·Perception·Ivan Bodis-Wollner
Nov 23, 2007·Journal of Neurophysiology·Clayton E Curtis, Jason D Connolly
Nov 10, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Michael S Salman, Kristin M Ikeda
Sep 30, 2016·Journal of Neurophysiology·Rebecca M Krock, Tirin Moore
Mar 31, 1999·Current Opinion in Neurology·B Gaymard, C Pierrot-Deseilligny
Aug 12, 2000·Journal of Neurophysiology·J Xing, R A Andersen
Sep 29, 2004·The European Journal of Neuroscience·Thomas NyffelerRené M Müri
Jul 4, 2008·Journal of Neurophysiology·Masaki Isoda, Okihide Hikosaka
Aug 19, 2007·Journal of Neurophysiology·S F W NeggersJ L Kenemans
May 30, 2006·Nature Neuroscience·Veit Stuphorn, Jeffrey D Schall
May 21, 2011·AJNR. American Journal of Neuroradiology·M WalterfangD Velakoulis
Jun 8, 2011·The European Journal of Neuroscience·Masaki Isoda, Okihide Hikosaka
Mar 2, 2016·Experimental Brain Research·Nicolas WattiezPierre Pouget
Dec 3, 2003·Journal of Neurophysiology·Nelly AmadorJohn Schlag
Jun 5, 2010·Clinical EEG and Neuroscience·Ivan Bodis-Wollner
Jun 8, 2011·The European Journal of Neuroscience·Jeffrey D SchallThomas J Palmeri
Jun 1, 2010·Nature Neuroscience·Petroc SumnerKrish D Singh

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