PMID: 7528197Aug 1, 1994Paper

Interaction of thyroid hormone and functional overload on skeletal muscle isomyosin expression

Journal of Applied Physiology
S J SwoapK M Baldwin

Abstract

This study examined the interaction of exogenous thyroid hormone 3,5,3'-triiodothyronine (T3) and functional overload on skeletal muscle myosin heavy chain (MHC) expression, studied at both the protein and mRNA level of analysis. Animals were allocated to the following groups: 1) normal control, 2) overload control, 3) hyperthyroid control, and 4) hyperthyroid+overload. Overload of the rat plantaris was accomplished by surgical removal of its synergists (soleus and gastrocnemius), and the animals were made hyperthyroid by injections of T3 (350 micrograms/kg every other day). After overload of 8 wk, muscle enlargement occurred by 53% for both overload groups (P < 0.05). This was accompanied by a 330 and 82% increase in the relative content of type I and IIa MHC, respectively, and a corresponding decrease by 16 and 44% in type IIx and IIb MHC, respectively, in the overload control group (P < 0.05 vs. normal control). Changes in the relative and absolute content of mRNA for these MHCs paralleled the protein response. Exogenous T3 completely reversed the upregulation of type I MHC and the downregulation of type IIx associated with overload at both the protein and mRNA level (P < 0.05). However, T3 was only partially effective in bl...Continue Reading

Citations

Jan 1, 1997·Journal of Applied Physiology·V J CaiozzoK M Baldwin
Jul 13, 2004·Journal of Applied Physiology·Julia M GigerKenneth M Baldwin
Jun 28, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lucia H D Kang, Joseph F Y Hoh
Jun 11, 1998·Journal of Applied Physiology·F HaddadK M Baldwin
Oct 8, 1997·The American Journal of Physiology·V J CaiozzoK M Baldwin
Feb 7, 2001·American Journal of Physiology. Cell Physiology·V J CaiozzoK M Baldwin
Oct 1, 1996·Medicine and Science in Sports and Exercise·K M Baldwin
Dec 17, 2014·The Journal of Cell Biology·Duo ZhangHao Ying
Jul 1, 1997·Journal of Applied Physiology·R R RoyV R Edgerton
May 9, 1998·Journal of Applied Physiology·P E MozdziakE Schultz
Apr 8, 1998·The American Journal of Physiology·S J Swoap
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F YuL Larsson
Jun 8, 1999·The Anatomical Record·R J TalmadgeV R Edgerton
Oct 16, 2001·American Journal of Physiology. Cell Physiology·A X BigardR Ventura-Clapier
Jun 6, 2000·American Journal of Physiology. Cell Physiology·J M GigerK M Baldwin
Oct 24, 1997·Journal of Applied Physiology·C WrightK M Baldwin
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Julia M GigerKenneth M Baldwin

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