PMID: 6411490Aug 22, 1983Paper

Interaction of trifluoperazine with porcine calmodulin 19F NMR and induced CD spectral studies

FEBS Letters
T Shimizu, M Hatano

Abstract

We have used 19F NMR and CD spectra to study interactions of TFP with CaM under various conditions where no aggregation of TFP occurs. It was found that TFP is bound to CaM in the absence of Ca2+ with Ka greater than 4 X 10(4) M in terms of 19F NMR of TFP and that KCl markedly influences the interaction of TFP with CaM. It was also found that TFP causes quite strong induced CD bands corresponding with the absorption bands of the aromatic ring of TFP when TFP is bound to Ca2+-CaM. The induction of the CD bands was time-dependent and was composed of fast and slow phases.

References

Jan 1, 1973·Biopolymers·M HatanoY Kawamura
May 1, 1980·Journal of Biochemistry·M YazawaK Yagi
Jan 29, 1982·Biochemical and Biophysical Research Communications·R Gopalakrishna, W B Anderson
Mar 29, 1983·Biochemistry·J Gariépy, R S Hodges
Jun 30, 1982·Biochemical and Biophysical Research Communications·T ShimizuY Nozawa

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Citations

Apr 1, 1989·Journal of Protein Chemistry·P L PingerelliA L Schlaepfer
Jun 1, 1990·International Journal of Biological Macromolecules·Y OgomaM Hatano
Jan 1, 1989·Pharmacology & Therapeutics·M L VeiglW D Sedwick
Sep 2, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Paulami MandalTapan Ganguly
Apr 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J RobsonK R Acharya
Mar 21, 2008·Journal of Pharmaceutical Sciences·Andria L Skinner, Jennifer S Laurence

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