PMID: 9556133Apr 29, 1998Paper

Interaction of triiodothyronine with 1alpha,25-dihydroxyvitamin D3 on interleukin-6-dependent osteoclast-like cell formation in mouse bone marrow cell cultures

Bone
C SchillerM Peterlik

Abstract

In mouse bone marrow cultures, the formation of osteoclast-like, that is, tartrate-resistant acid phosphatase-positive (TRAP+) and calcitonin (CT) receptor-positive multinucleated cells (MNCs), induced by 10(-10) to 10(-8) mol/L 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], could be augmented by triiodothyronine (T3), which alone had no effect on osteoclast-like cell formation. The permissive effect of T3 increased the response to 1alpha,25(OH)2D3 by approximately one order of magnitude. Linear concentration dependence was observed between 10(-11) and 10(-8) mol/L T3. Importantly, inhibition of prostaglandin synthesis by indomethacin significantly impeded osteoclast-like cell formation by 1alpha,25(OH)2D3 and abrogated the effect of T3 thereon. Basal interleukin-6 (IL-6) production by cultured marrow cells was significantly stimulated by 1alpha,25(OH)2D3. However, even at an exceedingly high concentration of 20 ng/mL, IL-6 was ineffective in inducing osteoclast-like cell formation. Therefore, any hormonally induced rise in IL-6 release from bone marrow cells could not account for the observed changes in TRAP+ MNC numbers. Nevertheless, the stimulatory effect of 1alpha,25(OH)2D3 on osteoclastogenesis was partially dependent ...Continue Reading

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Citations

May 12, 2012·Nature Reviews. Immunology·Bruce R BlazarMehrdad Abedi
May 31, 2001·European Journal of Clinical Investigation·P PietschmannM Peterlik
Dec 31, 2003·The American Journal of Chinese Medicine·Qing-Hua SongJong-Chol Cyong
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M FlanaganM A Horton
Apr 25, 2000·Biochemical and Biophysical Research Communications·R GruberM Peterlik
Feb 28, 2002·Biochemical and Biophysical Research Communications·Masako MiuraKazuwa Nakao
Feb 5, 2002·Molecular Genetics and Metabolism·Clare B HarveyGraham R Williams
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Ashraf A RagabEdward M Greenfield
Sep 17, 2003·European Journal of Oral Sciences·Paola EspositoSergio Caputi
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Cecília H A Gouveia
Nov 16, 2021·In Vitro Cellular & Developmental Biology. Animal·Chengjian YuYabin Wang

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