PMID: 2495338Feb 1, 1989Paper

Interaction of vanadate with monosaccharides and nucleosides: a multinuclear NMR study

Journal of Inorganic Biochemistry
C F Geraldes, M M Castro

Abstract

Proton, 13C and 51V nuclear magnetic resonance spectroscopy has been used to study the interaction of vanadate with several molecules containing more than one hydroxyl group, including various aldoses and nucleosides. The aldoses D-mannose and D-ribose mainly form tridentate complexes, of trigonal bipyramidal geometry, with vanadate at pH 7. These sugars use three consecutive hydroxyl groups, cis to each other, of their pyranose forms to bind vanadate in those cyclic triesters. Other aldoses, like D-glucose, which do not have this unique structural characteristic, do not form tridentate complexes, but can form weaker bidentate cyclic diesters using two consecutive pyranose cis hydroxyl groups. Of course, the pyranose forms of D-mannose and D-ribose, as well as the furanose form of D-ribose, also yield cyclic diesters of vanadate. All these aldoses form weak monodentate noncyclic monoesters of tetrahedral geometry using a single hydroxyl group. The nucleosides uridine, cytidine and adenosine form two complexes of trigonal bipyramidal geometry with vanadate. In these complexes, having 1:1 and 2:1 ligand-to-metal stoichiometries, the nucleosides form cyclic diesters with vanadate using their C2, and C3, hydroxyl groups.

References

Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A S Tracey, M J Gresser
Sep 15, 1985·The Biochemical Journal·P CsermelyA J Ejchart
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Citations

Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·D Rehder
Aug 28, 1990·Biochemistry·C R CremoJ C Grammer
Nov 1, 1989·Journal of Inorganic Biochemistry·C F Geraldes, M M Castro
Oct 24, 2001·Inorganic Chemistry·Kajal Krishna RajakAnimesh Chakravorty
Jan 16, 2003·Inorganic Chemistry·K K RajakA Chakravorty

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